Category: news feed

  • Exploring the potential of long cell-free DNA in cancer liquid biopsy

    Exploring the potential of long cell-free DNA in cancer liquid biopsy

    Cancer is one of the leading causes of death. One in four people will suffer from cancer in their life time. Many cancers are asymptomatic in early stage. When patients are diagnosed with cancer, they are often in advanced stages, leading to a poorer survival. The key to conquer the disease is to detect cancer at its early stage. Traditionally, cancer diagnosis relies on invasive methods such as tissue biopsy, which can cause complications such as pain, infections and injuries to surrounding organs. As such, there has been an increasing interest in the development of non-invasive methods for cancer testing. This emerging field is called ‘liquid biopsy’…

    (more…)

  • Exploring the potential of long cell-free DNA in cancer liquid biopsy

    Exploring the potential of long cell-free DNA in cancer liquid biopsy

    Cancer is one of the leading causes of death. One in four people will suffer from cancer in their life time. Many cancers are asymptomatic in early stage. When patients are diagnosed with cancer, they are often in advanced stages, leading to a poorer survival. The key to conquer the disease is to detect cancer at its early stage. Traditionally, cancer diagnosis relies on invasive methods such as tissue biopsy, which can cause complications such as pain, infections and injuries to surrounding organs. As such, there has been an increasing interest in the development of non-invasive methods for cancer testing. This emerging field is called ‘liquid biopsy’…

    (more…)

  • 長片段游離DNA: 癌症檢測新路向

    長片段游離DNA: 癌症檢測新路向

    癌症在人類眾多殺手中名列前茅,每四個人之中就有一個人會患上癌症。不少早期癌症都沒有任何徵狀。當病人感到不適而求醫時,往往已是癌症晚期,大大降低生存機會。因此,不少科學家都致力研發早期癌症診斷方法,希望能及早診斷出癌症並提供治療,以挽救更多生命。傳統上我們依靠入侵性方法,如活組織檢查作癌症診斷。然而,這些入侵性方法可能導致痛楚、感染或誤傷附近的器官,不少人因而卻步。有見及此,科學界正努力研發各種無創癌症檢測方法,讓癌症檢測變得更安全。這新興領域稱為「液體活檢」…

    (more…)

  • 長片段游離DNA: 癌症檢測新路向

    長片段游離DNA: 癌症檢測新路向

    癌症在人類眾多殺手中名列前茅,每四個人之中就有一個人會患上癌症。不少早期癌症都沒有任何徵狀。當病人感到不適而求醫時,往往已是癌症晚期,大大降低生存機會。因此,不少科學家都致力研發早期癌症診斷方法,希望能及早診斷出癌症並提供治療,以挽救更多生命。傳統上我們依靠入侵性方法,如活組織檢查作癌症診斷。然而,這些入侵性方法可能導致痛楚、感染或誤傷附近的器官,不少人因而卻步。有見及此,科學界正努力研發各種無創癌症檢測方法,讓癌症檢測變得更安全。這新興領域稱為「液體活檢」…

    (more…)

  • 长片段游离DNA: 癌症检测新路向

    长片段游离DNA: 癌症检测新路向

    癌症在人类众多杀手中名列前茅,每四个人之中就有一个人会患上癌症。不少早期癌症都没有任何征状。当病人感到不适而求医时,往往已是癌症晚期,大大降低生存机会。因此,不少科学家都致力研发早期癌症诊断方法,希望能及早诊断出癌症并提供治疗,以挽救更多生命。传统上我们依靠入侵性方法,如活组织检查作癌症诊断。然而,这些入侵性方法可能导致痛楚、感染或误伤附近的器官,不少人因而却步。有见及此,科学界正努力研发各种无创癌症检测方法,让癌症检测变得更安全。这新兴领域称为「液体活检」…

    (more…)

  • 长片段游离DNA: 癌症检测新路向

    长片段游离DNA: 癌症检测新路向

    癌症在人类众多杀手中名列前茅,每四个人之中就有一个人会患上癌症。不少早期癌症都没有任何征状。当病人感到不适而求医时,往往已是癌症晚期,大大降低生存机会。因此,不少科学家都致力研发早期癌症诊断方法,希望能及早诊断出癌症并提供治疗,以挽救更多生命。传统上我们依靠入侵性方法,如活组织检查作癌症诊断。然而,这些入侵性方法可能导致痛楚、感染或误伤附近的器官,不少人因而却步。有见及此,科学界正努力研发各种无创癌症检测方法,让癌症检测变得更安全。这新兴领域称为「液体活检」…

    (more…)

  • Cluster-Based Aircraft Fuel Estimation Model for Effective and Efficient Fuel Budgeting on New Routes

    Cluster-Based Aircraft Fuel Estimation Model for Effective and Efficient Fuel Budgeting on New Routes

    Abstract: Fuel burn accounts for up to 25% of an aircraft’s total operating cost and has become one of the most important decision factors in the airline industry. Hence, prudent fuel estimation is essential for airlines to ensure smooth operation in the upcoming financial year. Challenges arise when airlines need to estimate the total fuel consumption of new sectors where data are not available. This necessitates the derivation of a robust parametric model that can represent the characteristics of the new route even in the absence of relevant data. To address this issue, we propose a two-step approach to derive a model that can accurately estimate the aircraft fuel needed. The developed approach involves both unsupervised learning and a regression model. For the unsupervised learning step, hierarchical density-based spatial clustering of applications with noise (HDBSCAN) is used to cluster the principal component analysis (PCA)-reduced data. This step can automatically separate flight sectors based on their underlying characteristics, as revealed by their principal components, upon filtering the noise in the data. Afterward, multivariate linear regression (MLR) is used to derive the equations for each cluster. The PCA-based clustered model is shown to be superior to using a global model for a single aircraft type. This approach yields fuel estimation with less than 5% root mean square error for existing routes within each cluster. More importantly, the proposed method can accurately estimate the total fuel of a new route with less than 2% aggregate error, thereby addressing one of the current limitations in the airline fuel estimation study…

    (more…)

  • 用以對新航線所需燃料作出髙效預算的飛機燃料聚類估算模型

    用以對新航線所需燃料作出髙效預算的飛機燃料聚類估算模型

    摘要:燃料消耗佔飛機的整體營運成本比例達 25%,是航空公司至為重大的決策因素之一。因此,對燃料消耗作出審慎的估算,是航空公司在未來一個財政年度裏確保順利營運的關鍵工作。當航空公司需要估算新航段的總燃料消耗量,而又未能掌握所需數據時,就會出現困難。這便需要有一個強大的參數模型,即使在缺乏相關數據的情況下,也可以借助該模型所描繪的新航線特徵,來作出相關推演工作。為解決這個問題,我們提出一個涉及兩個步驟的方法,來得出一個可用以準確地估算所需飛機燃料的模型。這個構建出來的方法既涉及無監督學習,也涉及一個迴歸模型。對於無監督學習步驟,採用「基於分層密度之噪聲應用空間聚類法」(HDBSCAN),來對經過主成分分析 (PCA) 方法歸約出的數據進行聚類處理。這個步驟可以在過濾數據中的噪聲後,根據各個航段的主要成分所顯示的基本特徵,自動分類不同的航段。然後,使用多元線性迴歸法 (MLR) 推演出每個聚類的公式。主要成分分析基礎聚類模型被證明優勝於對單一飛機類型採用一通用的模型。對於每個聚類內的現有航線,使用這種方法得出的燃料估算之均方根誤差小於 5%。更重要的是,這個建議使用的方法可用以準確地估算新航線所需的總燃料,總誤差小於 2%,因此能夠解決航空公司燃料估算研究的其中一個現有局限性。

    (more…)

  • 用以对新航线所需燃料作出髙效预算的飞机燃料聚类估算模型

    用以对新航线所需燃料作出髙效预算的飞机燃料聚类估算模型

    摘要:燃料消耗占飞机的整体营运成本比例达 25%,是航空公司至为重大的决策因素之一。因此,对燃料消耗作出审慎的估算,是航空公司在未来一个财政年度里确保顺利营运的关键工作。当航空公司需要估算新航段的总燃料消耗量,而又未能掌握所需数据时,就会出现困难。这便需要有一个强大的参数模型,即使在缺乏相关数据的情况下,也可以借助该模型所描绘的新航线特征,来作出相关推演工作。为解决这个问题,我们提出一个涉及两个步骤的方法,来得出一个可用以准确地估算所需飞机燃料的模型。这个构建出来的方法既涉及无监督学习,也涉及一个回归模型。对于无监督学习步骤,采用「基于分层密度之噪声应用空间聚类法」(HDBSCAN),来对经过主成分分析 (PCA) 方法归约出的数据进行聚类处理。这个步骤可以在过滤数据中的噪声后,根据各个航段的主要成分所显示的基本特征,自动分类不同的航段。然后,使用多元线性回归法 (MLR) 推演出每个聚类的公式。主要成分分析基础聚类模型被证明优胜于对单一飞机类型采用一通用的模型。对于每个聚类内的现有航线,使用这种方法得出的燃料估算之均方根误差小于 5%。更重要的是,这个建议使用的方法可用以准确地估算新航线所需的总燃料,总误差小于 2%,因此能够解决航空公司燃料估算研究的其中一个现有局限性。

    (more…)

  • Dog’s Nose in Your Everyday Devices: Next Generation Gas Sensors Enabled by Porous Materials Chemistry

    Dog’s Nose in Your Everyday Devices: Next Generation Gas Sensors Enabled by Porous Materials Chemistry

    A dog’s nose is regarded as one of the most powerful sensors that exist. Trained canines are even able to detect various clinical conditions, such as spikes in blood sugar and cholesterol levels, by sniffing the affected person. For routine clinical examinations, we would need a more practical and cost-effective way to “sniff”. For my PhD project, my research was centered on developing a new method of integrating a ‘dog’s nose’-like system in our everyday device, using a material called metal-organic frameworks…

    (more…)