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Author: uniquekey
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newsletter (June 2023 – Issue 21)
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newsletter (June 2023 – Issue 21)
关于香港桂冠论坛欢迎大家来到香港桂冠论坛2023年6月份通讯。
「香港桂冠论坛新闻发布会及启动礼」已于6月6日圆满举行,标志著首届香港桂冠论坛正式启动。活动当天,香港特区政府创新科技及工业局局长孙东教授, JP,联同香港桂冠论坛委员会主席唐伟章教授, BBS, JP、李兆基基金董事林高演博士, SBS和邵逸夫奖理事会主席杨纲凯教授莅临主礼,并分别发表了简洁而有力的致辞。随后,大会航空赞助伙伴国泰航空代表莫佩雅女士、两间论坛的合作机构,即港铁代表李婉玲女士及投资推广署代表黄炜卓先生,亦就香港的科研在商业方面的发展作出分享。藉著这个机会,我们再次感谢主要赞助机构李兆基基金和主要合作伙伴邵逸夫奖基金会对论坛的无私付出。我们亦感谢香港特区政府,特别是创新科技及工业局及投资推广署、国泰航空及港铁对论坛各项任务的全力支持。一直以港为家的国泰航空除了为邵逸夫奖得奖者提供商务机票,亦为香港桂冠论坛的出席者提供特选礼遇,诚意为出席者及同行旅伴献上专享的票价优惠,展开更称心的旅程。
至于新闻发布会及启动礼的精华片段,欢迎大家到我们的YouTube频道收看。论坛委员会亦为出席新闻发布会的非本地媒体代表举办了一个参观本地大学的「香港桂冠论坛传媒导赏团」,请参阅下一篇文章以了解更多。
论坛将于11月13至18日在香港科学园举行,主题为「汇聚顶尖思维.启发科学成就」,将汇聚来自世界各地在天文学、生命科学与医学、数学科学三大领域中取得卓越成就的20多位邵逸夫奖得奖者亲临香港,通过研讨会、讲座和对谈会等,与全球来自超过30个不同国家及地区逾200名青年科学家分享他们的顶尖研究及对科研的真知灼见。论坛某些环节将同时设有现场直播,让世界各地的学者以至年轻一代能透过网上平台参与论坛。有关论坛的活动概览,请到我们的网站细阅。
除积极筹备论坛以外,我们亦已于5月开展连续第二年举办的「香港桂冠论坛中学生科学探索者奖励计划2023/2024」,旨在鼓励中学生参加和科学相关活动,以扩阔他们的视野和得到启发。奖励计划的首个活动「邵逸夫奖得奖者公众讲座︰黑洞的活跃社会生活」已于6月24日顺利举行,由2020年邵逸夫天文学奖得奖者罗杰•布兰福德亲身到香港太空馆演讲厅讲授关于我们对天体物理中黑洞的基本理解的重大突破和关键问题,出席讲座的中学生均踊跃发问,而他们对天体物理学的了解无疑是更深入透彻。有关更多奖励计划的活动,请浏览我们的网站。
我们一直在社区推动科学交流,于4月时与香港资优教育学苑签订合作框架协议,建立策略伙伴关系,共同推广STEAM教育,借此提升资优生对科学及科技方面的兴趣,从而为本地培养科研人才。我们除了于4月份邀请了论坛活动指导委员会成员香港中文大学卓敏物理学教授朱明中教授担任学苑举办的天文学课程研究成果发布的嘉宾,论坛亦于6月17日与学苑首次合办科学对谈。活动先由朱明中教授向于天文学课程中表现最优秀的三位资优学员分享他探究天文学的旅程,随后他带领大家参观中大物理系实验室,三位资优学员均被展示的各种设备及其功能所吸引。最后,朱教授、学苑院长黄金耀博士及论坛秘书长杜彭慧仪女士跟三位学员分享对科学的重要性的看法,并鼓励他们追求自己热爱的科目。
除了致力向年轻一代推广科学,气候变化也是我们非常关心的议题。我们热衷于支持关注这个议题的活动,而我们很高兴成为了低碳想创坊主办的ASECCC (Asia Solar Energy for Climate Change Conference)的支持机构。会议将于8月23至25日在网上进行,透过汇聚亚太地区不同领域的专家,推动太阳能的倡议及应对气候变化,迈向可更持续发展的未来。有关ASECCC的详情,请按此参阅。
最后,5月14日是论坛委员会成立四周年的日子,我们由衷感谢各方好友一直以来对我们的支持,并期待与各界继续携手合作,推动香港科学和科技各个领域的教育和交流。
香港桂冠论坛传媒导赏团桂冠论坛委员会特意于6月5至8日举办了一个四日三夜的传媒导赏团,安排多间应邀出席「香港桂冠论坛新闻发布会及启动礼」的非本地媒体机构代表参观本地著名大学的顶尖科研设施,与一众科学家及研究团队会面交流,了解香港最新的科研发展。我们亦为受邀传媒提供更多首届论坛的资讯,期望把此亚洲大型科学盛事带给更多人认识。
受邀传媒包括驻港及非驻港的媒体机构代表,他们分别来自中国内地,包括北京、上海、深圳等,亦有来自南韩、泰国及越南,而不少媒体机构代表均表示非常高兴能亲身到访本地大学。透过参观及体验不同的科研设施,及访问科学家们,我们深信受邀传媒能把香港的科研发展及成果带给不同地方的受众。
桂冠论坛感谢大学的支持、筹备及款待,使传媒导赏团得以顺利举行,及感谢一众主持的科学家详尽介绍各个研究项目及设施,当中包括:
香港中文大学
- 中大InnoHK研究中心:香港微生物菌群创新中心—陈家亮教授、黄秀娟教授及其研究团队
- 中大InnoHK研究中心:医疗机械人创新技术中心—欧国威教授、赵伟仁教授及其研究团队
- 农业生物技术国家重点实验室—林汉明教授及其研究团队
香港理工大学
- 国家轨道交通电气化与自动化工程技术研究中心(香港分中心)—倪一清教授及其研究团队
- 深空探测研究中心—容启亮教授及其研究团队
香港科技大学
- 生物冷冻电镜中心—张盈怡博士及其研究团队
- 纳米系统制造实验中心—陈敬教授及其研究团队
- 分子神经科学国家重点实验室—傅洁瑜教授及其研究团队
- 空气动力学和声学实验中心—周朋教授及其研究团队
香港大学
- 合成化学国家重点实验室—支志明教授及其研究团队
- 谭荣芬创科翼—崔俊杰博士及其研究团队
我们期待于11月论坛举行期间,带领更多传媒及参加论坛的青年科学家拜访本地大学不同的科研设施,以展示香港最新的科研项目。
用以对新航线所需燃料作出髙效预算的飞机燃料聚类估算模型摘要:燃料消耗占飞机的整体营运成本比例达 25%,是航空公司至为重大的决策因素之一。因此,对燃料消耗作出审慎的估算,是航空公司在未来一个财政年度里确保顺利营运的关键工作。当航空公司需要估算新航段的总燃料消耗量,而又未能掌握所需数据时,就会出现困难。这便需要有一个强大的参数模型,即使在缺乏相关数据的情况下,也可以借助该模型所描绘的新航线特征,来作出相关推演工作。为解决这个问题,我们提出一个涉及两个步骤的方法,来得出一个可用以准确地估算所需飞机燃料的模型。这个构建出来的方法既涉及无监督学习,也涉及一个回归模型。对于无监督学习步骤,采用「基于分层密度之噪声应用空间聚类法」(HDBSCAN),来对经过主成分分析 (PCA) 方法归约出的数据进行聚类处理。这个步骤可以在过滤数据中的噪声后,根据各个航段的主要成分所显示的基本特征,自动分类不同的航段。然后,使用多元线性回归法 (MLR) 推演出每个聚类的公式。主要成分分析基础聚类模型被证明优胜于对单一飞机类型采用一通用的模型。对于每个聚类内的现有航线,使用这种方法得出的燃料估算之均方根误差小于 5%。更重要的是,这个建议使用的方法可用以准确地估算新航线所需的总燃料,总误差小于 2%,因此能够解决航空公司燃料估算研究的其中一个现有局限性。
1. 简介
航空大数据分析在近年以来已经成为一个新兴的研究领域。由于数据的收集和储存方面有所进步,数据驱动模型或机器学习技术已广泛地应用于不同的行业,而航空业也不例外。采用这些技术,能帮助从任何特定的数据集中发现有意义的模式和知识。先前使用这些技术在航空领域进行的研究之结果,已在航空交通管理、飞机意外调查、飞行运作异常、航空公司飞机性能等不同方面得到体现。
由于燃料成本占航空公司总营运开支的 17-25%,航空公司的一个飞机性能关注点就是燃料消耗量 [7]。正因为燃料预算决定了航空公司在未来一年的盈利能力,因此,具有可靠而且准确的燃料估算模型,对于航空公司来说十分重要。燃料预算取决于耗用的燃料数量及预期的燃料价格。我们明白,燃料价格的波动是决定燃料预算的一个关键因素 [8, 9]。但是,燃料价格的预测不在这项研究的范围之中,而且我们假设各家航空公司都有适当的策略和政策来应对燃料价格的波动问题。在这项研究中,我们聚焦于估算在制定燃料预算时考虑的燃料数量,我们在下文将其称为燃料消耗估算。为尽量降低由于燃料计划欠妥造成的损失,有必要实现高度准确的总燃料预测。
作者:
香港科技大学机械及航空航天工程系助理教授Rhea Liem教授
香港科技大学机械及航空航天工程系博士生Jefry YANTO先生
日常设备中的狗鼻子:采用透气材料化学制成的新一代气体感应器狗的鼻子被认为是世界上其中一种至为强大的感应器。经过训练的狗只甚至能够藉著嗅闻病人身体,即可侦测到多种临床状况,例如血糖和胆固醇水平飙升的情况。在日常的临床检验当中,我们需要一种更加实用、更具成本效益的“嗅闻”方法。我的博士研究项目重点是开发一种新方法,使用一种称为金属有机框架的材料,将一个类似于“狗鼻子”的系统整合到我们的日常设备里。
日常最广为人知的电子鼻是呼吸分析仪。接受呼吸测试的司机向呼吸分析仪呼气时,藏在这个设备里的感应器便会将受测试者呼吸中的浓度进行对比,从而测量他们体内的酒精含量。酒精分子与呼吸分析仪中的活性感应材料之间的化学相互作用会转化为电子讯号,让调查员读取结果。人的呼吸中的酒精相对较易侦测出来,因为酒精有特定的化学成分,而且酒精的浓度一般较高(即使受测试者没有过量喝酒)。但是,我们的呼吸中包含著很多由浓度非常低的气体分子组成的复杂混合物。要构建先进的电子鼻来侦测低浓度的特定分子并不容易(这里的低浓度是指百万分点浓度 (ppm) 级别,大约相当于一个奥运规格泳池里的一滴水)。幸好,化学和材料科学能够为克服这一限制提供解决方案。现在,我们可以使用一种称为金属有机框架 (MOF) 的材料来构建未来灵敏度甚高的电子鼻。
作者︰
Dr Alexander John Cruz, Technology Integration Leader – Climate Technology Solutions, Baker Hughes
从流感到新冠病毒病:是否需要每年接种SARS-CoV-2疫苗?经过三年的戴口罩生活和旅行限制,大部分与新冠病毒病相关的限制在2023年3月被解除。虽然香港市民的情绪得到了提升,但新冠病毒病例和流感病例的数量正在上升。全球的科学家一直在监测SARS-CoV-2的演变,并有报告显示病毒在不断变异,以及血液中的抗体水平下降。这引出了一个问题:我们需要每年接种SARS-CoV-2疫苗加强剂吗?
疫苗接种是一种模拟由病原体构建的物质自然感染的程序,这些物质可以是较不具威胁性的病原体(灭活的)、病原体的一部分(蛋白质亚基)或如mRNA疫苗等新的平台。在自然感染或疫苗接种后,我们的免疫系统会产生针对该病原体的记忆细胞,当我们再次遇到相同的病原体时,这些记忆细胞会迅速作出反应。一个快速的免疫反应可以抑制病原体的复制,并减少对我们身体的损害。此外,如果病原体的数量被抑制,传染给他人的风险也会降低。因此,疫苗可以减少传染病的感染率和疾病严重程度。
作者︰
Mr Khong Ka Wa
MBBS 6, the University of Hong Kong
一个都不能遗漏:栅栏错误你要在下午一时至四时完成科目一至四的功课。如果你每小时完成一份就能准时完成所有功课,对或错?
如果是五月一日至四日呢?如果每天做一份,你能及时跟功课说再见吗?
这些问题背后引伸出更多问题:为甚么小时跟日子的算法会有所不同?我们应怎样数起?学校教的知识应用起来永远不会像想像中简单 — 显浅如数算事物也是如此。
要搞清楚这一连串的问题,我们先要回到幼稚园。我们学会如何从一、二、三……数算物件,亦学会这个数算过程让我们知道物件的数量 — 不论是铅笔、房子或是日子。为了简化事情,我们为物件标上数字并以此代替数算:六月的日子被标上数字1至30,顺理成章地六月就有30天。
然后我们学习减法。老师拿著六枝铅笔,再把当中四枝逐枝取走,借此示范6 – 4 = 2。减法是算术运算的一种,指把物件数目改变的动作(「运算」),在上述例子即是取走铅笔的动作。现在我们考虑的是稍为不同的概念:两个数字之间的间距,这可不是数字本身!在学习数线之后,我们以由6到2之间的四个箭头表示6 – 4 = 2:
它们清楚表示减法考虑的是由2到6之间的四个「间距」,但这次运算其实「碰」到了五个数字:2、3、4、5、6。
作者︰ 胡适之 《科言》学生编辑 香港科技大学
设计︰ Samantha Ng 《科言》学生设计师 香港科技大学
翻译: 刘劭行 《科言》总编辑 香港科技大学
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newsletter (June 2023 – Issue 21)
關於香港桂冠論壇歡迎大家來到香港桂冠論壇2023年6月份通訊。
「香港桂冠論壇新聞發佈會及啟動禮」已於6月6日圓滿舉行,標誌著首屆香港桂冠論壇正式啟動。活動當天,香港特區政府創新科技及工業局局長孫東教授, JP,聯同香港桂冠論壇委員會主席唐偉章教授, BBS, JP、李兆基基金董事林高演博士, SBS和邵逸夫獎理事會主席楊綱凱教授蒞臨主禮,並分別發表了簡潔而有力的致辭。隨後,大會航空贊助伙伴國泰航空代表莫佩雅女士、兩間論壇的合作機構,即港鐵代表李婉玲女士及投資推廣署代表黃煒卓先生,亦就香港的科研在商業方面的發展作出分享。藉著這個機會,我們再次感謝主要贊助機構李兆基基金和主要合作夥伴邵逸夫獎基金會對論壇的無私付出。我們亦感謝香港特區政府,特別是創新科技及工業局及投資推廣署、國泰航空及港鐵對論壇各項任務的全力支持。一直以港為家的國泰航空除了為邵逸夫獎得獎者提供商務機票,亦為香港桂冠論壇的出席者提供特選禮遇,誠意為出席者及同行旅伴獻上專享的票價優惠,展開更稱心的旅程。
至於新聞發佈會及啟動禮的精華片段,歡迎大家到我們的YouTube頻道收看。論壇委員會亦為出席新聞發佈會的非本地媒體代表舉辦了一個參觀本地大學的「香港桂冠論壇傳媒導賞團」,請參閱下一篇文章以了解更多。
論壇將於11月13至18日在香港科學園舉行,主題為「匯聚頂尖思維.啟發科學成就」,將匯聚來自世界各地在天文學、生命科學與醫學、數學科學三大領域中取得卓越成就的20多位邵逸夫獎得獎者親臨香港,通過研討會、講座和對談會等,與全球來自超過30個不同國家及地區逾200名青年科學家分享他們的頂尖研究及對科研的真知灼見。論壇某些環節將同時設有現場直播,讓世界各地的學者以至年輕一代能透過網上平台參與論壇。有關論壇的活動概覽,請到我們的網站細閱。
除積極籌備論壇以外,我們亦已於5月開展連續第二年舉辦的「香港桂冠論壇中學生科學探索者獎勵計劃2023/2024」,旨在鼓勵中學生參加和科學相關活動,以擴闊他們的視野和得到啟發。獎勵計劃的首個活動「邵逸夫獎得獎者公眾講座︰黑洞的活躍社會生活」已於6月24日順利舉行,由2020年邵逸夫天文學獎得獎者羅傑•布蘭福德親身到香港太空館演講廳講授關於我們對天體物理中黑洞的基本理解的重大突破和關鍵問題,出席講座的中學生均踴躍發問,而他們對天體物理學的了解無疑是更深入透徹。有關更多獎勵計劃的活動,請瀏覽我們的網站。
我們一直在社區推動科學交流,於4月時與香港資優教育學苑簽訂合作框架協議,建立策略夥伴關係,共同推廣STEAM教育,藉此提升資優生對科學及科技方面的興趣,從而為本地培養科研人才。我們除了於4月份邀請了論壇活動指導委員會成員香港中文大學卓敏物理學教授朱明中教授擔任學苑舉辦的天文學課程研究成果發佈的嘉賓,論壇亦於6月17日與學苑首次合辦科學對談。活動先由朱明中教授向於天文學課程中表現最優秀的三位資優學員分享他探究天文學的旅程,隨後他帶領大家參觀中大物理系實驗室,三位資優學員均被展示的各種設備及其功能所吸引。最後,朱教授、學苑院長黃金耀博士及論壇秘書長杜彭慧儀女士跟三位學員分享對科學的重要性的看法,並鼓勵他們追求自己熱愛的科目。
除了致力向年輕一代推廣科學,氣候變化也是我們非常關心的議題。我們熱衷於支持關注這個議題的活動,而我們很高興成為了低碳想創坊主辦的ASECCC (Asia Solar Energy for Climate Change Conference)的支持機構。會議將於8月23至25日在網上進行,透過匯聚亞太地區不同領域的專家,推動太陽能的倡議及應對氣候變化,邁向可更持續發展的未來。有關ASECCC的詳情,請按此參閱。
最後,5月14日是論壇委員會成立四周年的日子,我們由衷感謝各方好友一直以來對我們的支持,並期待與各界繼續攜手合作,推動香港科學和科技各個領域的教育和交流。
香港桂冠論壇傳媒導賞團桂冠論壇委員會特意於6月5至8日舉辦了一個四日三夜的傳媒導賞團,安排多間應邀出席「香港桂冠論壇新聞發佈會及啟動禮」的非本地媒體機構代表參觀本地著名大學的頂尖科研設施,與一眾科學家及研究團隊會面交流,了解香港最新的科研發展。我們亦為受邀傳媒提供更多首屆論壇的資訊,期望把此亞洲大型科學盛事帶給更多人認識。
受邀傳媒包括駐港及非駐港的媒體機構代表,他們分別來自中國內地,包括北京、上海、深圳等,亦有來自南韓、泰國及越南,而不少媒體機構代表均表示非常高興能親身到訪本地大學。透過參觀及體驗不同的科研設施,及訪問科學家們,我們深信受邀傳媒能把香港的科研發展及成果帶給不同地方的受眾。
桂冠論壇感謝大學的支持、籌備及款待,使傳媒導賞團得以順利舉行,及感謝一眾主持的科學家詳盡介紹各個研究項目及設施,當中包括:
香港中文大學
- 中大InnoHK研究中心:香港微生物菌群創新中心—陳家亮教授、黃秀娟教授及其研究團隊
- 中大InnoHK研究中心:醫療機械人創新技術中心—歐國威教授、趙偉仁教授及其研究團隊
- 農業生物技術國家重點實驗室—林漢明教授及其研究團隊
香港理工大學
- 國家軌道交通電氣化與自動化工程技術研究中心(香港分中心)—倪一清教授及其研究團隊
- 深空探測研究中心—容啟亮教授及其研究團隊
香港科技大學
- 生物冷凍電鏡中心—張盈怡博士及其研究團隊
- 納米系統製造實驗中心—陳敬教授及其研究團隊
- 分子神經科學國家重點實驗室—傅潔瑜教授及其研究團隊
- 空氣動力學和聲學實驗中心—周朋教授及其研究團隊
香港大學
- 合成化學國家重點實驗室—支志明教授及其研究團隊
- 譚榮芬創科翼—崔俊傑博士及其研究團隊
我們期待於11月論壇舉行期間,帶領更多傳媒及參加論壇的青年科學家拜訪本地大學不同的科研設施,以展示香港最新的科研項目。
用以對新航線所需燃料作出髙效預算的飛機燃料聚類估算模型摘要:燃料消耗佔飛機的整體營運成本比例達 25%,是航空公司至為重大的決策因素之一。因此,對燃料消耗作出審慎的估算,是航空公司在未來一個財政年度裏確保順利營運的關鍵工作。當航空公司需要估算新航段的總燃料消耗量,而又未能掌握所需數據時,就會出現困難。這便需要有一個強大的參數模型,即使在缺乏相關數據的情況下,也可以借助該模型所描繪的新航線特徵,來作出相關推演工作。為解決這個問題,我們提出一個涉及兩個步驟的方法,來得出一個可用以準確地估算所需飛機燃料的模型。這個構建出來的方法既涉及無監督學習,也涉及一個迴歸模型。對於無監督學習步驟,採用「基於分層密度之噪聲應用空間聚類法」(HDBSCAN),來對經過主成分分析 (PCA) 方法歸約出的數據進行聚類處理。這個步驟可以在過濾數據中的噪聲後,根據各個航段的主要成分所顯示的基本特徵,自動分類不同的航段。然後,使用多元線性迴歸法 (MLR) 推演出每個聚類的公式。主要成分分析基礎聚類模型被證明優勝於對單一飛機類型採用一通用的模型。對於每個聚類內的現有航線,使用這種方法得出的燃料估算之均方根誤差小於 5%。更重要的是,這個建議使用的方法可用以準確地估算新航線所需的總燃料,總誤差小於 2%,因此能夠解決航空公司燃料估算研究的其中一個現有局限性。
1. 簡介
航空大數據分析在近年以來已經成為一個新興的研究領域。由於數據的收集和儲存方面有所進步,數據驅動模型或機器學習技術已廣泛地應用於不同的行業,而航空業也不例外。採用這些技術,能幫助從任何特定的數據集中發現有意義的模式和知識。先前使用這些技術在航空領域進行的研究之結果,已在航空交通管理、飛機意外調查、飛行運作異常、航空公司飛機性能等不同方面得到體現。
由於燃料成本佔航空公司總營運開支的 17-25%,航空公司的一個飛機性能關注點就是燃料消耗量 [7]。正因為燃料預算決定了航空公司在未來一年的盈利能力,因此,具有可靠而且準確的燃料估算模型,對於航空公司來說十分重要。燃料預算取決於耗用的燃料數量及預期的燃料價格。我們明白,燃料價格的波動是決定燃料預算的一個關鍵因素 [8, 9]。但是,燃料價格的預測不在這項研究的範圍之中,而且我們假設各家航空公司都有適當的策略和政策來應對燃料價格的波動問題。在這項研究中,我們聚焦於估算在制定燃料預算時考慮的燃料數量,我們在下文將其稱為燃料消耗估算。為儘量降低由於燃料計劃欠妥造成的損失,有必要實現高度準確的總燃料預測。
作者:
香港科技大學機械及航空航天工程系助理教授Rhea Liem教授
香港科技大學機械及航空航天工程系博士生Jefry YANTO先生
日常設備中的狗鼻子:採用透氣材料化學製成的新一代氣體感應器狗的鼻子被認為是世界上其中一種至為強大的感應器。經過訓練的狗隻甚至能夠藉著嗅聞病人身體,即可偵測到多種臨床狀況,例如血糖和膽固醇水平飆升的情況。在日常的臨床檢驗當中,我們需要一種更加實用、更具成本效益的“嗅聞”方法。我的博士研究項目重點是開發一種新方法,使用一種稱為金屬有機框架的材料,將一個類似於“狗鼻子”的系統整合到我們的日常設備裏。
日常最廣為人知的電子鼻是呼吸分析儀。接受呼吸測試的司機向呼吸分析儀呼氣時,藏在這個設備裏的感應器便會將受測試者呼吸中的濃度進行對比,從而測量他們體內的酒精含量。酒精分子與呼吸分析儀中的活性感應材料之間的化學相互作用會轉化為電子訊號,讓調查員讀取結果。人的呼吸中的酒精相對較易偵測出來,因為酒精有特定的化學成分,而且酒精的濃度一般較高(即使受測試者沒有過量喝酒)。但是,我們的呼吸中包含著很多由濃度非常低的氣體分子組成的複雜混合物。要構建先進的電子鼻來偵測低濃度的特定分子並不容易(這裏的低濃度是指百萬分點濃度 (ppm) 級別,大約相當於一個奧運規格泳池裏的一滴水)。幸好,化學和材料科學能夠為克服這一限制提供解決方案。現在,我們可以使用一種稱為金屬有機框架 (MOF) 的材料來構建未來靈敏度甚高的電子鼻。
作者︰
Dr Alexander John Cruz, Technology Integration Leader – Climate Technology Solutions, Baker Hughes
從流感到新冠病毒病:是否需要每年接種SARS-CoV-2疫苗?經過三年的戴口罩生活和旅行限制,大部分與新冠病毒病相關的限制在2023年3月被解除。雖然香港市民的情緒得到了提升,但新冠病毒病例和流感病例的數量正在上升。全球的科學家一直在監測SARS-CoV-2的演變,並有報告顯示病毒在不斷變異,以及血液中的抗體水平下降。這引出了一個問題:我們需要每年接種SARS-CoV-2疫苗加強劑嗎?
疫苗接種是一種模擬由病原體構建的物質自然感染的程序,這些物質可以是較不具威脅性的病原體(滅活的)、病原體的一部分(蛋白質亞基)或如mRNA疫苗等新的平台。在自然感染或疫苗接種後,我們的免疫系統會產生針對該病原體的記憶細胞,當我們再次遇到相同的病原體時,這些記憶細胞會迅速作出反應。一個快速的免疫反應可以抑制病原體的複製,並減少對我們身體的損害。此外,如果病原體的數量被抑制,傳染給他人的風險也會降低。因此,疫苗可以減少傳染病的感染率和疾病嚴重程度。
作者︰
Mr Khong Ka Wa
MBBS 6, the University of Hong Kong
一個都不能遺漏:柵欄錯誤你要在下午一時至四時完成科目一至四的功課。如果你每小時完成一份就能準時完成所有功課,對或錯?
如果是五月一日至四日呢?如果每天做一份,你能及時跟功課說再見嗎?
這些問題背後引伸出更多問題:為甚麼小時跟日子的算法會有所不同?我們應怎樣數起?學校教的知識應用起來永遠不會像想像中簡單 — 顯淺如數算事物也是如此。
要搞清楚這一連串的問題,我們先要回到幼稚園。我們學會如何從一、二、三……數算物件,亦學會這個數算過程讓我們知道物件的數量 — 不論是鉛筆、房子或是日子。為了簡化事情,我們為物件標上數字並以此代替數算:六月的日子被標上數字1至30,順理成章地六月就有30天。
然後我們學習減法。老師拿著六枝鉛筆,再把當中四枝逐枝取走,藉此示範6 – 4 = 2。減法是算術運算的一種,指把物件數目改變的動作(「運算」),在上述例子即是取走鉛筆的動作。現在我們考慮的是稍為不同的概念:兩個數字之間的間距,這可不是數字本身!在學習數線之後,我們以由6到2之間的四個箭頭表示6 – 4 = 2:
它們清楚表示減法考慮的是由2到6之間的四個「間距」,但這次運算其實「碰」到了五個數字:2、3、4、5、6。
作者︰ 胡適之 《科言》學生編輯 香港科技大學
設計︰ Samantha Ng 《科言》學生設計師 香港科技大學
翻譯: 劉劭行 《科言》總編輯 香港科技大學
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newsletter (June 2023 – Issue 21)
关于香港桂冠论坛欢迎大家来到香港桂冠论坛2023年6月份通讯。
「香港桂冠论坛新闻发布会及启动礼」已于6月6日圆满举行,标志著首届香港桂冠论坛正式启动。活动当天,香港特区政府创新科技及工业局局长孙东教授, JP,联同香港桂冠论坛委员会主席唐伟章教授, BBS, JP、李兆基基金董事林高演博士, SBS和邵逸夫奖理事会主席杨纲凯教授莅临主礼,并分别发表了简洁而有力的致辞。随后,大会航空赞助伙伴国泰航空代表莫佩雅女士、两间论坛的合作机构,即港铁代表李婉玲女士及投资推广署代表黄炜卓先生,亦就香港的科研在商业方面的发展作出分享。藉著这个机会,我们再次感谢主要赞助机构李兆基基金和主要合作伙伴邵逸夫奖基金会对论坛的无私付出。我们亦感谢香港特区政府,特别是创新科技及工业局及投资推广署、国泰航空及港铁对论坛各项任务的全力支持。一直以港为家的国泰航空除了为邵逸夫奖得奖者提供商务机票,亦为香港桂冠论坛的出席者提供特选礼遇,诚意为出席者及同行旅伴献上专享的票价优惠,展开更称心的旅程。
至于新闻发布会及启动礼的精华片段,欢迎大家到我们的YouTube频道收看。论坛委员会亦为出席新闻发布会的非本地媒体代表举办了一个参观本地大学的「香港桂冠论坛传媒导赏团」,请参阅下一篇文章以了解更多。
论坛将于11月13至18日在香港科学园举行,主题为「汇聚顶尖思维.启发科学成就」,将汇聚来自世界各地在天文学、生命科学与医学、数学科学三大领域中取得卓越成就的20多位邵逸夫奖得奖者亲临香港,通过研讨会、讲座和对谈会等,与全球来自超过30个不同国家及地区逾200名青年科学家分享他们的顶尖研究及对科研的真知灼见。论坛某些环节将同时设有现场直播,让世界各地的学者以至年轻一代能透过网上平台参与论坛。有关论坛的活动概览,请到我们的网站细阅。
除积极筹备论坛以外,我们亦已于5月开展连续第二年举办的「香港桂冠论坛中学生科学探索者奖励计划2023/2024」,旨在鼓励中学生参加和科学相关活动,以扩阔他们的视野和得到启发。奖励计划的首个活动「邵逸夫奖得奖者公众讲座︰黑洞的活跃社会生活」已于6月24日顺利举行,由2020年邵逸夫天文学奖得奖者罗杰•布兰福德亲身到香港太空馆演讲厅讲授关于我们对天体物理中黑洞的基本理解的重大突破和关键问题,出席讲座的中学生均踊跃发问,而他们对天体物理学的了解无疑是更深入透彻。有关更多奖励计划的活动,请浏览我们的网站。
我们一直在社区推动科学交流,于4月时与香港资优教育学苑签订合作框架协议,建立策略伙伴关系,共同推广STEAM教育,借此提升资优生对科学及科技方面的兴趣,从而为本地培养科研人才。我们除了于4月份邀请了论坛活动指导委员会成员香港中文大学卓敏物理学教授朱明中教授担任学苑举办的天文学课程研究成果发布的嘉宾,论坛亦于6月17日与学苑首次合办科学对谈。活动先由朱明中教授向于天文学课程中表现最优秀的三位资优学员分享他探究天文学的旅程,随后他带领大家参观中大物理系实验室,三位资优学员均被展示的各种设备及其功能所吸引。最后,朱教授、学苑院长黄金耀博士及论坛秘书长杜彭慧仪女士跟三位学员分享对科学的重要性的看法,并鼓励他们追求自己热爱的科目。
除了致力向年轻一代推广科学,气候变化也是我们非常关心的议题。我们热衷于支持关注这个议题的活动,而我们很高兴成为了低碳想创坊主办的ASECCC (Asia Solar Energy for Climate Change Conference)的支持机构。会议将于8月23至25日在网上进行,透过汇聚亚太地区不同领域的专家,推动太阳能的倡议及应对气候变化,迈向可更持续发展的未来。有关ASECCC的详情,请按此参阅。
最后,5月14日是论坛委员会成立四周年的日子,我们由衷感谢各方好友一直以来对我们的支持,并期待与各界继续携手合作,推动香港科学和科技各个领域的教育和交流。
香港桂冠论坛传媒导赏团桂冠论坛委员会特意于6月5至8日举办了一个四日三夜的传媒导赏团,安排多间应邀出席「香港桂冠论坛新闻发布会及启动礼」的非本地媒体机构代表参观本地著名大学的顶尖科研设施,与一众科学家及研究团队会面交流,了解香港最新的科研发展。我们亦为受邀传媒提供更多首届论坛的资讯,期望把此亚洲大型科学盛事带给更多人认识。
受邀传媒包括驻港及非驻港的媒体机构代表,他们分别来自中国内地,包括北京、上海、深圳等,亦有来自南韩、泰国及越南,而不少媒体机构代表均表示非常高兴能亲身到访本地大学。透过参观及体验不同的科研设施,及访问科学家们,我们深信受邀传媒能把香港的科研发展及成果带给不同地方的受众。
桂冠论坛感谢大学的支持、筹备及款待,使传媒导赏团得以顺利举行,及感谢一众主持的科学家详尽介绍各个研究项目及设施,当中包括:
香港中文大学
- 中大InnoHK研究中心:香港微生物菌群创新中心—陈家亮教授、黄秀娟教授及其研究团队
- 中大InnoHK研究中心:医疗机械人创新技术中心—欧国威教授、赵伟仁教授及其研究团队
- 农业生物技术国家重点实验室—林汉明教授及其研究团队
香港理工大学
- 国家轨道交通电气化与自动化工程技术研究中心(香港分中心)—倪一清教授及其研究团队
- 深空探测研究中心—容启亮教授及其研究团队
香港科技大学
- 生物冷冻电镜中心—张盈怡博士及其研究团队
- 纳米系统制造实验中心—陈敬教授及其研究团队
- 分子神经科学国家重点实验室—傅洁瑜教授及其研究团队
- 空气动力学和声学实验中心—周朋教授及其研究团队
香港大学
- 合成化学国家重点实验室—支志明教授及其研究团队
- 谭荣芬创科翼—崔俊杰博士及其研究团队
我们期待于11月论坛举行期间,带领更多传媒及参加论坛的青年科学家拜访本地大学不同的科研设施,以展示香港最新的科研项目。
用以对新航线所需燃料作出髙效预算的飞机燃料聚类估算模型摘要:燃料消耗占飞机的整体营运成本比例达 25%,是航空公司至为重大的决策因素之一。因此,对燃料消耗作出审慎的估算,是航空公司在未来一个财政年度里确保顺利营运的关键工作。当航空公司需要估算新航段的总燃料消耗量,而又未能掌握所需数据时,就会出现困难。这便需要有一个强大的参数模型,即使在缺乏相关数据的情况下,也可以借助该模型所描绘的新航线特征,来作出相关推演工作。为解决这个问题,我们提出一个涉及两个步骤的方法,来得出一个可用以准确地估算所需飞机燃料的模型。这个构建出来的方法既涉及无监督学习,也涉及一个回归模型。对于无监督学习步骤,采用「基于分层密度之噪声应用空间聚类法」(HDBSCAN),来对经过主成分分析 (PCA) 方法归约出的数据进行聚类处理。这个步骤可以在过滤数据中的噪声后,根据各个航段的主要成分所显示的基本特征,自动分类不同的航段。然后,使用多元线性回归法 (MLR) 推演出每个聚类的公式。主要成分分析基础聚类模型被证明优胜于对单一飞机类型采用一通用的模型。对于每个聚类内的现有航线,使用这种方法得出的燃料估算之均方根误差小于 5%。更重要的是,这个建议使用的方法可用以准确地估算新航线所需的总燃料,总误差小于 2%,因此能够解决航空公司燃料估算研究的其中一个现有局限性。
1. 简介
航空大数据分析在近年以来已经成为一个新兴的研究领域。由于数据的收集和储存方面有所进步,数据驱动模型或机器学习技术已广泛地应用于不同的行业,而航空业也不例外。采用这些技术,能帮助从任何特定的数据集中发现有意义的模式和知识。先前使用这些技术在航空领域进行的研究之结果,已在航空交通管理、飞机意外调查、飞行运作异常、航空公司飞机性能等不同方面得到体现。
由于燃料成本占航空公司总营运开支的 17-25%,航空公司的一个飞机性能关注点就是燃料消耗量 [7]。正因为燃料预算决定了航空公司在未来一年的盈利能力,因此,具有可靠而且准确的燃料估算模型,对于航空公司来说十分重要。燃料预算取决于耗用的燃料数量及预期的燃料价格。我们明白,燃料价格的波动是决定燃料预算的一个关键因素 [8, 9]。但是,燃料价格的预测不在这项研究的范围之中,而且我们假设各家航空公司都有适当的策略和政策来应对燃料价格的波动问题。在这项研究中,我们聚焦于估算在制定燃料预算时考虑的燃料数量,我们在下文将其称为燃料消耗估算。为尽量降低由于燃料计划欠妥造成的损失,有必要实现高度准确的总燃料预测。
作者:
香港科技大学机械及航空航天工程系助理教授Rhea Liem教授
香港科技大学机械及航空航天工程系博士生Jefry YANTO先生
日常设备中的狗鼻子:采用透气材料化学制成的新一代气体感应器狗的鼻子被认为是世界上其中一种至为强大的感应器。经过训练的狗只甚至能够藉著嗅闻病人身体,即可侦测到多种临床状况,例如血糖和胆固醇水平飙升的情况。在日常的临床检验当中,我们需要一种更加实用、更具成本效益的“嗅闻”方法。我的博士研究项目重点是开发一种新方法,使用一种称为金属有机框架的材料,将一个类似于“狗鼻子”的系统整合到我们的日常设备里。
日常最广为人知的电子鼻是呼吸分析仪。接受呼吸测试的司机向呼吸分析仪呼气时,藏在这个设备里的感应器便会将受测试者呼吸中的浓度进行对比,从而测量他们体内的酒精含量。酒精分子与呼吸分析仪中的活性感应材料之间的化学相互作用会转化为电子讯号,让调查员读取结果。人的呼吸中的酒精相对较易侦测出来,因为酒精有特定的化学成分,而且酒精的浓度一般较高(即使受测试者没有过量喝酒)。但是,我们的呼吸中包含著很多由浓度非常低的气体分子组成的复杂混合物。要构建先进的电子鼻来侦测低浓度的特定分子并不容易(这里的低浓度是指百万分点浓度 (ppm) 级别,大约相当于一个奥运规格泳池里的一滴水)。幸好,化学和材料科学能够为克服这一限制提供解决方案。现在,我们可以使用一种称为金属有机框架 (MOF) 的材料来构建未来灵敏度甚高的电子鼻。
作者︰
Dr Alexander John Cruz, Technology Integration Leader – Climate Technology Solutions, Baker Hughes
从流感到新冠病毒病:是否需要每年接种SARS-CoV-2疫苗?经过三年的戴口罩生活和旅行限制,大部分与新冠病毒病相关的限制在2023年3月被解除。虽然香港市民的情绪得到了提升,但新冠病毒病例和流感病例的数量正在上升。全球的科学家一直在监测SARS-CoV-2的演变,并有报告显示病毒在不断变异,以及血液中的抗体水平下降。这引出了一个问题:我们需要每年接种SARS-CoV-2疫苗加强剂吗?
疫苗接种是一种模拟由病原体构建的物质自然感染的程序,这些物质可以是较不具威胁性的病原体(灭活的)、病原体的一部分(蛋白质亚基)或如mRNA疫苗等新的平台。在自然感染或疫苗接种后,我们的免疫系统会产生针对该病原体的记忆细胞,当我们再次遇到相同的病原体时,这些记忆细胞会迅速作出反应。一个快速的免疫反应可以抑制病原体的复制,并减少对我们身体的损害。此外,如果病原体的数量被抑制,传染给他人的风险也会降低。因此,疫苗可以减少传染病的感染率和疾病严重程度。
作者︰
Mr Khong Ka Wa
MBBS 6, the University of Hong Kong
一个都不能遗漏:栅栏错误你要在下午一时至四时完成科目一至四的功课。如果你每小时完成一份就能准时完成所有功课,对或错?
如果是五月一日至四日呢?如果每天做一份,你能及时跟功课说再见吗?
这些问题背后引伸出更多问题:为甚么小时跟日子的算法会有所不同?我们应怎样数起?学校教的知识应用起来永远不会像想像中简单 — 显浅如数算事物也是如此。
要搞清楚这一连串的问题,我们先要回到幼稚园。我们学会如何从一、二、三……数算物件,亦学会这个数算过程让我们知道物件的数量 — 不论是铅笔、房子或是日子。为了简化事情,我们为物件标上数字并以此代替数算:六月的日子被标上数字1至30,顺理成章地六月就有30天。
然后我们学习减法。老师拿著六枝铅笔,再把当中四枝逐枝取走,借此示范6 – 4 = 2。减法是算术运算的一种,指把物件数目改变的动作(「运算」),在上述例子即是取走铅笔的动作。现在我们考虑的是稍为不同的概念:两个数字之间的间距,这可不是数字本身!在学习数线之后,我们以由6到2之间的四个箭头表示6 – 4 = 2:
它们清楚表示减法考虑的是由2到6之间的四个「间距」,但这次运算其实「碰」到了五个数字:2、3、4、5、6。
作者︰ 胡适之 《科言》学生编辑 香港科技大学
设计︰ Samantha Ng 《科言》学生设计师 香港科技大学
翻译: 刘劭行 《科言》总编辑 香港科技大学
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newsletter (Oct 2023 – Issue 22)
About the Hong Kong Laureate ForumWelcome to the October 2023 issue of the newsletter of the Hong Kong Laureate Forum!
The inaugural Hong Kong Laureate Forum (the Forum), fully sponsored by the Lee Shau Kee Foundation, is around the corner! The Forum, with its theme “Meeting of Inspirational Minds”, will kick off on 13 November at the Hong Kong Science Park and will bring together over 20 Shaw Laureates, as well as other world-renowned scientists, along with around 200 young scientists from 30 countries and regions to participate in the week-long programmes. Our preparation work for the Forum is in full swing and we are finalising the details of the arrangements. The Forum will feature a wide range of programmes, including keynote speeches by Shaw Laureates, breakout sessions with Shaw Laureates and world-renowned scientists, poster presentation by young scientists, trending topic sessions, etc. The areas under discussion will mainly cover the three Shaw Prize disciplines, namely, Astronomy, Life Science and Medicine, and Mathematical Sciences. Shaw Laureates and distinguished scientists invited to the Forum will share their profound insights in their respective research areas through their speeches and panel discussions. To provide a glimpse of what is to come, here are some of the exciting topics we will be exploring: “The Tidal Disruption of Stars by Black Holes”, “Channelrhodopsins in transgene animals or plants: chances and challenge” and “Fourier transform as a triangular matrix”, etc. Several Forum speakers will also be invited to share and discuss on the impact of new technology on two important aspects, namely scientific research and higher education. This global trending topic will be deliberated through two inter-related sessions, viz, “Impact of New Technology on Scientific Development” and “AI and the Teaching of Science”.
In addition, we will invite Shaw Laureates to have dialogues with secondary students and visit secondary schools, with a view to enhance the understanding and interests of the young generation in Hong Kong in various disciplines in science and technology. Moreover, it would be an opportunity for Shaw Laureates to experience first-hand local secondary school life. We are also collaborating with our academic partners to lead young scientists to visit local universities so as to deepen their understanding of research development at these institutions. Furthermore, the Forum participants will visit InnoHK centres, HKSTP Experience Centre and Hong Kong Research & Development Centres, including Hong Kong Research Institute of Textiles and Apparel, Logistics and Supply Chain MultiTech R&D Centre, and Nano and Advanced Materials Institute, which will expose Forum participants to various ongoing research projects in Hong Kong. We will also co-organise a half-day programme named “Knowledge Transfer, from R&D to application” with Cyberport – Hong Kong’s Digital Technology Hub, which will allow Forum participants to learn about the development of digital technology in Hong Kong. To provide a taste on public science education, the official programmes will include visits to Hong Kong Science Museum and Hong Kong Space Museum, and they will attend science seminars to be organised by the HKLF in collaborations with the said museums, titled “Kaleidoscope of Protein Folding” and “Stars’ Journey in our Milky Way Galaxy” respectively. These two seminars will be open to the public and local secondary students. Apart from academic exchanges, there will also be cross-cultural events for Forum participants, these include a tour to the West Kowloon Cultural District and a special reception featuring local delicacies, offering opportunities for Forum participants to experience Hong Kong’s culture. For more information about the Forum’s programmes, sessions with live streaming and details of the seminars that will be open to the public, please stay tuned to our website and social media! To bring the Forum to a wide audience around the world, we will invite local media and representatives from media organisations, with or without local offices, from outside Hong Kong to join this major academic exchange event and to report on the ventures of some of the brightest minds in the scientific world.
Indeed, as a prominent event in Hong Kong’s academic community, the Forum has already attracted significant media attention. Both our Chairman, Professor Timothy Tong, and Board member, Professor Young have been interviewed by different media outlets to share their thoughts on their expectation of what the Forum would achieve. To find out more, please read the interviews below:
Furthermore, the valuable Insights and perspectives of the Forum from members of the Programme Steering Committee and one of the participating young scientists will be shared through various media channels. Stay tuned!
While actively preparing for the Forum, we strive to keep promoting scientific development in the community through different means. In July, we co-organised the “Scientists and Their Contributions Voxel Art Design Contest” with Index Game and The Sandbox, with the aim to promote understanding and interests of the young generation in Hong Kong in various disciplines in science and technology through an emerging channel. The competition, open for registration in early July, received enthusiastic responses with over 20 teams from various secondary school students participating. The teams attended the VoxEdit workshops and consultation sessions in September, where they learned to use the VoxEdit tool to create voxel characters. The competition results will be announced through our website and social media later this month and the winning voxel art will be 3D printed and exhibited during the Forum.
Besides, the annual InnoCarnival organised by the Innovation and Technology Commission is coming soon. InnoCarnival 2023 will be held from 28 October to 5 November at the Hong Kong Science Park. Same as previous years, the HKLF will be one of the participating organisations among over 35 exhibition and game booths. This year, we will once again collaborate with the Consulate General of France in Hong Kong and Macau to incorporate a virtual reality (VR) component at the HKLF’s booth to showcase the planets and to uncover the music and sounds of the cosmos, with the aim to offering visitors a unique and engaging perspective on the wonders of the universe. In addition to the VR experience, the HKLF booth will feature other interactive games as well. Please visit our booth and have a fun time wandering through space, blowing your mind with mathematicsal intrigues and winning exciting prizes! Visit InnoCarnival’s website for more details.
Evidence for a new Type of Memory with Implications for Understanding Consciousness and PerceptionAbstract:
Consciousness is at the heart of our every experience but still poorly understood scientifically. New research offers insights into how weak and ambiguous stimuli can be consciously perceived through repetition and offers evidence for a new type of memory—a subliminal sensory buffer store (SSBS)—which has been predicted by one of the leading theories of consciousness. Experimental data also shows that visual masking, a widely used technique in psychology and neuroscience, does not erase or overwrite information as was previously thought but merely limits conscious access to it. These findings have a profound impact on consciousness studies and cognitive science in general.
1. Introduction
Consciousness is at the same time what we know best and a complete mystery. Every experience we ever had is the result of our own consciousness. Yet, despite our intimate familiarity with it, consciousness is difficult to define and poorly understood scientifically. We know more about distant galaxies and the deepest regions of the oceans than about the basis for our own experiences. A leading neuroscientist wagered in 1998 that the neural mechanisms of consciousness would be discovered within 25 years. He recently conceded his bet lost. While a complete understanding of consciousness remains elusive, tremendous progress has still been made in this field. As recently as 1996, the International Dictionary of Psychology’s entry on consciousness stated that “nothing worth reading has been written about it”. Now, there are countless books, journals, laboratories, and entire research departments dedicated to this field of enquiry. One fruitful avenue has been to study perception and explore the difference between consciously perceived stimuli and those that remain unconscious. A common way to control the visibility of stimuli is through masking.
Authors:
Mr Damian K F Pang, MSc
The Mutual Benefits of Cohabitation of Solar Panel System and HorticultureThe increasing occurrence of extreme weather events over the past few years has underscored the impact of climate change is having on our planet. As a developed city that has set itself a target of carbon neutrality by the year 2050, Hong Kong must do everything within its power to reduce its carbon emissions in order to contain the global temperature rise to below 1.5°C. Despite Hong Kong’s potential to expand the use of renewable energy, the scarcity of the territory’s land resources means that on top of fierce competition on the usage of every piece of land, owners are already maximising the utility of every square inch on their plot.
In order to improve the visual appeal of urban environments and mitigate urban heat island effects, building owners and property managers are finding ways to carry out greening, such as by transforming conventional roofs into green ones. At the same time, there are also people choosing to install solar photovoltaic systems on their rooftops so as to obtain extra electricity and earn income generated from the Feed-in Tariff (FiT). In addition, some property developers in Hong Kong are considering installing solar panels on unused farmland in a drive to optimise land use. It may seem counterintuitive to combine solar power systems with the cultivation of plants or crops as plants need water, sunlight and soil for growth, and covering them with solar photovoltaic systems goes against the fundamental requirements for their growth. However, with careful planning, these two approaches can be mutually beneficial as well as maximise the utility of our valuable space. This article will explore the advantages, challenges and precautions so required of combining solar photovoltaic systems with greening projects or crop cultivation on rooftops or farmland in Hong Kong.
Solar power in Hong Kong
To truly transition towards a low-carbon economy, it is crucial that Hong Kong increases the proportion of renewable energy in its total energy generation. Hong Kong’s Climate Action Plan 2050 sets out the long-term goal of achieving carbon net zero in its power generation by 2050, with the proportion of its energy coming from renewable sources rising from less than 1% today to 7.5-10% by 2035, and 15% by 2050. As part of this strategy, installing solar power systems on rooftops, hence, is becoming more prevalent. For example, the Action Plan states that new government buildings must dedicate 25% of their available rooftop area to the installation of renewable energy systems, which is significantly higher than the 10% previously stipulated. The Housing Authority similarly must install solar power systems on all new buildings in public housing estates, with a view to using these to generate at least 1.5% of the public electricity supply.
In truth, these targets are relatively low and far less ambitious than those set by other east Asian cities, which has led to criticism from environmental and climate change concerned groups. According to a study by The Hong Kong Polytechnic University, among the 309,000 buildings in Hong Kong, 233,000 are suitable for installing solar photovoltaic systems on their roof or rooftop, which would potentially be able to generate 4,674 GWh of solar energy every year — equivalent to 10.7% of Hong Kong’s energy needs. Hong Kong has had a FiT system in place since 2018, to encourage non-government organisations and private individuals to install renewable energy systems on their property. However, despite the fact that rooftop solar photovoltaic systems can provide an enormous source of renewable energy, the proportion of renewables in Hong Kong’s energy mix has barely risen in the past five years. In fact, the government even reduced the FiT in April 2022, leading to fears that it will discourage others from signing up as they would be unable to recoup the high set-up cost before the scheme’s end in 2033.
Authors:
Mr Kwok Hiu Chung, Senior Programme Officer, CarbonCare InnoLab
Mr Ken Tai, Project Manager, CarbonCare InnoLab
Ringdown: the music by oscillating black holes(1) Introduction
If you pluck a violin string, the string vibrates, driving the air particles around the string to oscillate too, setting up sound waves that propagate in the air. That is why you will hear a note. However, the note will not last long. Through generating sound, the string loses its vibrational energy in the air. The vibrations of the violin string decay. So does the note.Interestingly, a similar phenomenon occurs in perturbed black holes. As two black holes collide, they will merge into one larger and distorted black hole and generate enormous gravitational waves. The distorted black hole is an example of perturbed black hole. These gravitational waves are the oscillations of space-time near the new black hole. Similar to the vibrations of a violin string, the oscillations of black holes do not last long, because black holes are a unique type of celestial object that possesses an event horizon, a single direction highway which once entered, there is no way out. The energy of the gravitational waves propagating around a black hole will likewise dissipate either down to the black-hole horizon by absorption or propagating far away until the waves are far enough for us to detect. Either way, the energy of gravitational waves localised around a black hole is dissipating, and so are the oscillations of the black hole. When the oscillations die down, the distorted black hole becomes a quiet and stationary black hole. The process of a perturbed black hole settling down into a stationary one is called the ringdown phase of a black hole because the process resembles the ringing of musical instruments, such as a bell. Just as a violin string can vibrate in different modes (such as the fundamental mode and overtones), there are also different modes (patterns) of black-hole oscillations. These modes are called the quasinormal modes of black hole, and the oscillation frequencies are called the quasinormal-mode frequencies.
The black-hole ringdown phase is not just of interest to theoretical physics research. It is an actual astrophysical phenomenon which we have detected since the first direct detection of gravitational waves by the Advanced Laser Interferometer Gravitational-Wave Observatory (aLIGO) detectors. The late stage of the first detected gravitational-wave signal, GW150914, clearly shows a ringdown signal emitted by the remnant of a black hole formed by the corresponding black-hole coalescence. Since then, astrophysicists have been studying the ringdown signal contained in the detected gravitational-wave signals extensively.
Author:
Mr Adrian Ka-Wai Chung
Postdoc research associate, Department of Physics, University of Illinois Urbana-Champaign
Member, Illinois Center for Advanced Studies of the Universe
Exploring the potential of long cell-free DNA in cancer liquid biopsyCancer is one of the leading causes of death. One in four people will suffer from cancer in their life time. Many cancers are asymptomatic in early stage. When patients are diagnosed with cancer, they are often in advanced stages, leading to a poorer survival. The key to conquer the disease is to detect cancer at its early stage. Traditionally, cancer diagnosis relies on invasive methods such as tissue biopsy, which can cause complications such as pain, infections and injuries to surrounding organs. As such, there has been an increasing interest in the development of non-invasive methods for cancer testing. This emerging field is called ‘liquid biopsy’.
Recently, cell-free DNA (cfDNA) analysis in bodily fluids has become the focus of liquid biopsy. For instance, in a recent study involving plasma DNA analysis of 20,000 asymptomatic individuals conducted by our team at The Chinese University of Hong Kong, it has been revealed that the circulating Epstein-Barr virus DNA can serve as biomarker for screening nasopharyngeal carcinoma, making a paradigm shift in the proportion of cancer patients identified at early stage when the cancer can be cured. The survival rate was improved 10 times in screened individuals than those in historical cohort, bringing hope to cancer diagnostics using liquid biopsy. Apart from cancer screening, cfDNA analysis can also guide cancer treatment decisions. This is demonstrated by the detection of epidermal growth factor receptor (EGFR) mutations in the plasma of non-small cell lung cancer patients and the subsequent choice of targeted therapy for treatment.
As cfDNA-based liquid biopsy has gradually been gaining popularity in cancer diagnostics, there has been ongoing research efforts in enhancing the understanding of the properties of cfDNA. One key area of research would be epigenetics, which involves chemical modifications without alterations of DNA sequence. Of note, DNA methylation is an important type of epigenetic modification. Recently, based on methylation analysis of plasma DNA, not only could we diagnose cancer, the location of cancer could also be determined. This approach was subsequently applied to screen multiple cancers in a large prospective cohort of 6689 participants and led to the world’s first commercial product of a multi-cancer early detection test called ‘Galleri’ in the market.
Author:
Dr Lois Choy, Department of Chemical Pathology, The Chinese University of Hong Kong
-
newsletter (Oct 2023 – Issue 22)
About the Hong Kong Laureate ForumWelcome to the October 2023 issue of the newsletter of the Hong Kong Laureate Forum!
The inaugural Hong Kong Laureate Forum (the Forum), fully sponsored by the Lee Shau Kee Foundation, is around the corner! The Forum, with its theme “Meeting of Inspirational Minds”, will kick off on 13 November at the Hong Kong Science Park and will bring together over 20 Shaw Laureates, as well as other world-renowned scientists, along with around 200 young scientists from 30 countries and regions to participate in the week-long programmes. Our preparation work for the Forum is in full swing and we are finalising the details of the arrangements. The Forum will feature a wide range of programmes, including keynote speeches by Shaw Laureates, breakout sessions with Shaw Laureates and world-renowned scientists, poster presentation by young scientists, trending topic sessions, etc. The areas under discussion will mainly cover the three Shaw Prize disciplines, namely, Astronomy, Life Science and Medicine, and Mathematical Sciences. Shaw Laureates and distinguished scientists invited to the Forum will share their profound insights in their respective research areas through their speeches and panel discussions. To provide a glimpse of what is to come, here are some of the exciting topics we will be exploring: “The Tidal Disruption of Stars by Black Holes”, “Channelrhodopsins in transgene animals or plants: chances and challenge” and “Fourier transform as a triangular matrix”, etc. Several Forum speakers will also be invited to share and discuss on the impact of new technology on two important aspects, namely scientific research and higher education. This global trending topic will be deliberated through two inter-related sessions, viz, “Impact of New Technology on Scientific Development” and “AI and the Teaching of Science”.
In addition, we will invite Shaw Laureates to have dialogues with secondary students and visit secondary schools, with a view to enhance the understanding and interests of the young generation in Hong Kong in various disciplines in science and technology. Moreover, it would be an opportunity for Shaw Laureates to experience first-hand local secondary school life. We are also collaborating with our academic partners to lead young scientists to visit local universities so as to deepen their understanding of research development at these institutions. Furthermore, the Forum participants will visit InnoHK centres, HKSTP Experience Centre and Hong Kong Research & Development Centres, including Hong Kong Research Institute of Textiles and Apparel, Logistics and Supply Chain MultiTech R&D Centre, and Nano and Advanced Materials Institute, which will expose Forum participants to various ongoing research projects in Hong Kong. We will also co-organise a half-day programme named “Knowledge Transfer, from R&D to application” with Cyberport – Hong Kong’s Digital Technology Hub, which will allow Forum participants to learn about the development of digital technology in Hong Kong. To provide a taste on public science education, the official programmes will include visits to Hong Kong Science Museum and Hong Kong Space Museum, and they will attend science seminars to be organised by the HKLF in collaborations with the said museums, titled “Kaleidoscope of Protein Folding” and “Stars’ Journey in our Milky Way Galaxy” respectively. These two seminars will be open to the public and local secondary students. Apart from academic exchanges, there will also be cross-cultural events for Forum participants, these include a tour to the West Kowloon Cultural District and a special reception featuring local delicacies, offering opportunities for Forum participants to experience Hong Kong’s culture. For more information about the Forum’s programmes, sessions with live streaming and details of the seminars that will be open to the public, please stay tuned to our website and social media! To bring the Forum to a wide audience around the world, we will invite local media and representatives from media organisations, with or without local offices, from outside Hong Kong to join this major academic exchange event and to report on the ventures of some of the brightest minds in the scientific world.
Indeed, as a prominent event in Hong Kong’s academic community, the Forum has already attracted significant media attention. Both our Chairman, Professor Timothy Tong, and Board member, Professor Young have been interviewed by different media outlets to share their thoughts on their expectation of what the Forum would achieve. To find out more, please read the interviews below:
Furthermore, the valuable Insights and perspectives of the Forum from members of the Programme Steering Committee and one of the participating young scientists will be shared through various media channels. Stay tuned!
While actively preparing for the Forum, we strive to keep promoting scientific development in the community through different means. In July, we co-organised the “Scientists and Their Contributions Voxel Art Design Contest” with Index Game and The Sandbox, with the aim to promote understanding and interests of the young generation in Hong Kong in various disciplines in science and technology through an emerging channel. The competition, open for registration in early July, received enthusiastic responses with over 20 teams from various secondary school students participating. The teams attended the VoxEdit workshops and consultation sessions in September, where they learned to use the VoxEdit tool to create voxel characters. The competition results will be announced through our website and social media later this month and the winning voxel art will be 3D printed and exhibited during the Forum.
Besides, the annual InnoCarnival organised by the Innovation and Technology Commission is coming soon. InnoCarnival 2023 will be held from 28 October to 5 November at the Hong Kong Science Park. Same as previous years, the HKLF will be one of the participating organisations among over 35 exhibition and game booths. This year, we will once again collaborate with the Consulate General of France in Hong Kong and Macau to incorporate a virtual reality (VR) component at the HKLF’s booth to showcase the planets and to uncover the music and sounds of the cosmos, with the aim to offering visitors a unique and engaging perspective on the wonders of the universe. In addition to the VR experience, the HKLF booth will feature other interactive games as well. Please visit our booth and have a fun time wandering through space, blowing your mind with mathematicsal intrigues and winning exciting prizes! Visit InnoCarnival’s website for more details.
Evidence for a new Type of Memory with Implications for Understanding Consciousness and PerceptionAbstract:
Consciousness is at the heart of our every experience but still poorly understood scientifically. New research offers insights into how weak and ambiguous stimuli can be consciously perceived through repetition and offers evidence for a new type of memory—a subliminal sensory buffer store (SSBS)—which has been predicted by one of the leading theories of consciousness. Experimental data also shows that visual masking, a widely used technique in psychology and neuroscience, does not erase or overwrite information as was previously thought but merely limits conscious access to it. These findings have a profound impact on consciousness studies and cognitive science in general.
1. Introduction
Consciousness is at the same time what we know best and a complete mystery. Every experience we ever had is the result of our own consciousness. Yet, despite our intimate familiarity with it, consciousness is difficult to define and poorly understood scientifically. We know more about distant galaxies and the deepest regions of the oceans than about the basis for our own experiences. A leading neuroscientist wagered in 1998 that the neural mechanisms of consciousness would be discovered within 25 years. He recently conceded his bet lost. While a complete understanding of consciousness remains elusive, tremendous progress has still been made in this field. As recently as 1996, the International Dictionary of Psychology’s entry on consciousness stated that “nothing worth reading has been written about it”. Now, there are countless books, journals, laboratories, and entire research departments dedicated to this field of enquiry. One fruitful avenue has been to study perception and explore the difference between consciously perceived stimuli and those that remain unconscious. A common way to control the visibility of stimuli is through masking.
Authors:
Mr Damian K F Pang, MSc
The Mutual Benefits of Cohabitation of Solar Panel System and HorticultureThe increasing occurrence of extreme weather events over the past few years has underscored the impact of climate change is having on our planet. As a developed city that has set itself a target of carbon neutrality by the year 2050, Hong Kong must do everything within its power to reduce its carbon emissions in order to contain the global temperature rise to below 1.5°C. Despite Hong Kong’s potential to expand the use of renewable energy, the scarcity of the territory’s land resources means that on top of fierce competition on the usage of every piece of land, owners are already maximising the utility of every square inch on their plot.
In order to improve the visual appeal of urban environments and mitigate urban heat island effects, building owners and property managers are finding ways to carry out greening, such as by transforming conventional roofs into green ones. At the same time, there are also people choosing to install solar photovoltaic systems on their rooftops so as to obtain extra electricity and earn income generated from the Feed-in Tariff (FiT). In addition, some property developers in Hong Kong are considering installing solar panels on unused farmland in a drive to optimise land use. It may seem counterintuitive to combine solar power systems with the cultivation of plants or crops as plants need water, sunlight and soil for growth, and covering them with solar photovoltaic systems goes against the fundamental requirements for their growth. However, with careful planning, these two approaches can be mutually beneficial as well as maximise the utility of our valuable space. This article will explore the advantages, challenges and precautions so required of combining solar photovoltaic systems with greening projects or crop cultivation on rooftops or farmland in Hong Kong.
Solar power in Hong Kong
To truly transition towards a low-carbon economy, it is crucial that Hong Kong increases the proportion of renewable energy in its total energy generation. Hong Kong’s Climate Action Plan 2050 sets out the long-term goal of achieving carbon net zero in its power generation by 2050, with the proportion of its energy coming from renewable sources rising from less than 1% today to 7.5-10% by 2035, and 15% by 2050. As part of this strategy, installing solar power systems on rooftops, hence, is becoming more prevalent. For example, the Action Plan states that new government buildings must dedicate 25% of their available rooftop area to the installation of renewable energy systems, which is significantly higher than the 10% previously stipulated. The Housing Authority similarly must install solar power systems on all new buildings in public housing estates, with a view to using these to generate at least 1.5% of the public electricity supply.
In truth, these targets are relatively low and far less ambitious than those set by other east Asian cities, which has led to criticism from environmental and climate change concerned groups. According to a study by The Hong Kong Polytechnic University, among the 309,000 buildings in Hong Kong, 233,000 are suitable for installing solar photovoltaic systems on their roof or rooftop, which would potentially be able to generate 4,674 GWh of solar energy every year — equivalent to 10.7% of Hong Kong’s energy needs. Hong Kong has had a FiT system in place since 2018, to encourage non-government organisations and private individuals to install renewable energy systems on their property. However, despite the fact that rooftop solar photovoltaic systems can provide an enormous source of renewable energy, the proportion of renewables in Hong Kong’s energy mix has barely risen in the past five years. In fact, the government even reduced the FiT in April 2022, leading to fears that it will discourage others from signing up as they would be unable to recoup the high set-up cost before the scheme’s end in 2033.
Authors:
Mr Kwok Hiu Chung, Senior Programme Officer, CarbonCare InnoLab
Mr Ken Tai, Project Manager, CarbonCare InnoLab
Ringdown: the music by oscillating black holes(1) Introduction
If you pluck a violin string, the string vibrates, driving the air particles around the string to oscillate too, setting up sound waves that propagate in the air. That is why you will hear a note. However, the note will not last long. Through generating sound, the string loses its vibrational energy in the air. The vibrations of the violin string decay. So does the note.Interestingly, a similar phenomenon occurs in perturbed black holes. As two black holes collide, they will merge into one larger and distorted black hole and generate enormous gravitational waves. The distorted black hole is an example of perturbed black hole. These gravitational waves are the oscillations of space-time near the new black hole. Similar to the vibrations of a violin string, the oscillations of black holes do not last long, because black holes are a unique type of celestial object that possesses an event horizon, a single direction highway which once entered, there is no way out. The energy of the gravitational waves propagating around a black hole will likewise dissipate either down to the black-hole horizon by absorption or propagating far away until the waves are far enough for us to detect. Either way, the energy of gravitational waves localised around a black hole is dissipating, and so are the oscillations of the black hole. When the oscillations die down, the distorted black hole becomes a quiet and stationary black hole. The process of a perturbed black hole settling down into a stationary one is called the ringdown phase of a black hole because the process resembles the ringing of musical instruments, such as a bell. Just as a violin string can vibrate in different modes (such as the fundamental mode and overtones), there are also different modes (patterns) of black-hole oscillations. These modes are called the quasinormal modes of black hole, and the oscillation frequencies are called the quasinormal-mode frequencies.
The black-hole ringdown phase is not just of interest to theoretical physics research. It is an actual astrophysical phenomenon which we have detected since the first direct detection of gravitational waves by the Advanced Laser Interferometer Gravitational-Wave Observatory (aLIGO) detectors. The late stage of the first detected gravitational-wave signal, GW150914, clearly shows a ringdown signal emitted by the remnant of a black hole formed by the corresponding black-hole coalescence. Since then, astrophysicists have been studying the ringdown signal contained in the detected gravitational-wave signals extensively.
Author:
Mr Adrian Ka-Wai Chung
Postdoc research associate, Department of Physics, University of Illinois Urbana-Champaign
Member, Illinois Center for Advanced Studies of the Universe
Exploring the potential of long cell-free DNA in cancer liquid biopsyCancer is one of the leading causes of death. One in four people will suffer from cancer in their life time. Many cancers are asymptomatic in early stage. When patients are diagnosed with cancer, they are often in advanced stages, leading to a poorer survival. The key to conquer the disease is to detect cancer at its early stage. Traditionally, cancer diagnosis relies on invasive methods such as tissue biopsy, which can cause complications such as pain, infections and injuries to surrounding organs. As such, there has been an increasing interest in the development of non-invasive methods for cancer testing. This emerging field is called ‘liquid biopsy’.
Recently, cell-free DNA (cfDNA) analysis in bodily fluids has become the focus of liquid biopsy. For instance, in a recent study involving plasma DNA analysis of 20,000 asymptomatic individuals conducted by our team at The Chinese University of Hong Kong, it has been revealed that the circulating Epstein-Barr virus DNA can serve as biomarker for screening nasopharyngeal carcinoma, making a paradigm shift in the proportion of cancer patients identified at early stage when the cancer can be cured. The survival rate was improved 10 times in screened individuals than those in historical cohort, bringing hope to cancer diagnostics using liquid biopsy. Apart from cancer screening, cfDNA analysis can also guide cancer treatment decisions. This is demonstrated by the detection of epidermal growth factor receptor (EGFR) mutations in the plasma of non-small cell lung cancer patients and the subsequent choice of targeted therapy for treatment.
As cfDNA-based liquid biopsy has gradually been gaining popularity in cancer diagnostics, there has been ongoing research efforts in enhancing the understanding of the properties of cfDNA. One key area of research would be epigenetics, which involves chemical modifications without alterations of DNA sequence. Of note, DNA methylation is an important type of epigenetic modification. Recently, based on methylation analysis of plasma DNA, not only could we diagnose cancer, the location of cancer could also be determined. This approach was subsequently applied to screen multiple cancers in a large prospective cohort of 6689 participants and led to the world’s first commercial product of a multi-cancer early detection test called ‘Galleri’ in the market.
Author:
Dr Lois Choy, Department of Chemical Pathology, The Chinese University of Hong Kong
-
newsletter (Oct 2023 – Issue 22)
About the Hong Kong Laureate ForumWelcome to the October 2023 issue of the newsletter of the Hong Kong Laureate Forum!
The inaugural Hong Kong Laureate Forum (the Forum), fully sponsored by the Lee Shau Kee Foundation, is around the corner! The Forum, with its theme “Meeting of Inspirational Minds”, will kick off on 13 November at the Hong Kong Science Park and will bring together over 20 Shaw Laureates, as well as other world-renowned scientists, along with around 200 young scientists from 30 countries and regions to participate in the week-long programmes. Our preparation work for the Forum is in full swing and we are finalising the details of the arrangements. The Forum will feature a wide range of programmes, including keynote speeches by Shaw Laureates, breakout sessions with Shaw Laureates and world-renowned scientists, poster presentation by young scientists, trending topic sessions, etc. The areas under discussion will mainly cover the three Shaw Prize disciplines, namely, Astronomy, Life Science and Medicine, and Mathematical Sciences. Shaw Laureates and distinguished scientists invited to the Forum will share their profound insights in their respective research areas through their speeches and panel discussions. To provide a glimpse of what is to come, here are some of the exciting topics we will be exploring: “The Tidal Disruption of Stars by Black Holes”, “Channelrhodopsins in transgene animals or plants: chances and challenge” and “Fourier transform as a triangular matrix”, etc. Several Forum speakers will also be invited to share and discuss on the impact of new technology on two important aspects, namely scientific research and higher education. This global trending topic will be deliberated through two inter-related sessions, viz, “Impact of New Technology on Scientific Development” and “AI and the Teaching of Science”.
In addition, we will invite Shaw Laureates to have dialogues with secondary students and visit secondary schools, with a view to enhance the understanding and interests of the young generation in Hong Kong in various disciplines in science and technology. Moreover, it would be an opportunity for Shaw Laureates to experience first-hand local secondary school life. We are also collaborating with our academic partners to lead young scientists to visit local universities so as to deepen their understanding of research development at these institutions. Furthermore, the Forum participants will visit InnoHK centres, HKSTP Experience Centre and Hong Kong Research & Development Centres, including Hong Kong Research Institute of Textiles and Apparel, Logistics and Supply Chain MultiTech R&D Centre, and Nano and Advanced Materials Institute, which will expose Forum participants to various ongoing research projects in Hong Kong. We will also co-organise a half-day programme named “Knowledge Transfer, from R&D to application” with Cyberport – Hong Kong’s Digital Technology Hub, which will allow Forum participants to learn about the development of digital technology in Hong Kong. To provide a taste on public science education, the official programmes will include visits to Hong Kong Science Museum and Hong Kong Space Museum, and they will attend science seminars to be organised by the HKLF in collaborations with the said museums, titled “Kaleidoscope of Protein Folding” and “Stars’ Journey in our Milky Way Galaxy” respectively. These two seminars will be open to the public and local secondary students. Apart from academic exchanges, there will also be cross-cultural events for Forum participants, these include a tour to the West Kowloon Cultural District and a special reception featuring local delicacies, offering opportunities for Forum participants to experience Hong Kong’s culture. For more information about the Forum’s programmes, sessions with live streaming and details of the seminars that will be open to the public, please stay tuned to our website and social media! To bring the Forum to a wide audience around the world, we will invite local media and representatives from media organisations, with or without local offices, from outside Hong Kong to join this major academic exchange event and to report on the ventures of some of the brightest minds in the scientific world.
Indeed, as a prominent event in Hong Kong’s academic community, the Forum has already attracted significant media attention. Both our Chairman, Professor Timothy Tong, and Board member, Professor Young have been interviewed by different media outlets to share their thoughts on their expectation of what the Forum would achieve. To find out more, please read the interviews below:
Furthermore, the valuable Insights and perspectives of the Forum from members of the Programme Steering Committee and one of the participating young scientists will be shared through various media channels. Stay tuned!
While actively preparing for the Forum, we strive to keep promoting scientific development in the community through different means. In July, we co-organised the “Scientists and Their Contributions Voxel Art Design Contest” with Index Game and The Sandbox, with the aim to promote understanding and interests of the young generation in Hong Kong in various disciplines in science and technology through an emerging channel. The competition, open for registration in early July, received enthusiastic responses with over 20 teams from various secondary school students participating. The teams attended the VoxEdit workshops and consultation sessions in September, where they learned to use the VoxEdit tool to create voxel characters. The competition results will be announced through our website and social media later this month and the winning voxel art will be 3D printed and exhibited during the Forum.
Besides, the annual InnoCarnival organised by the Innovation and Technology Commission is coming soon. InnoCarnival 2023 will be held from 28 October to 5 November at the Hong Kong Science Park. Same as previous years, the HKLF will be one of the participating organisations among over 35 exhibition and game booths. This year, we will once again collaborate with the Consulate General of France in Hong Kong and Macau to incorporate a virtual reality (VR) component at the HKLF’s booth to showcase the planets and to uncover the music and sounds of the cosmos, with the aim to offering visitors a unique and engaging perspective on the wonders of the universe. In addition to the VR experience, the HKLF booth will feature other interactive games as well. Please visit our booth and have a fun time wandering through space, blowing your mind with mathematicsal intrigues and winning exciting prizes! Visit InnoCarnival’s website for more details.
Evidence for a new Type of Memory with Implications for Understanding Consciousness and PerceptionAbstract:
Consciousness is at the heart of our every experience but still poorly understood scientifically. New research offers insights into how weak and ambiguous stimuli can be consciously perceived through repetition and offers evidence for a new type of memory—a subliminal sensory buffer store (SSBS)—which has been predicted by one of the leading theories of consciousness. Experimental data also shows that visual masking, a widely used technique in psychology and neuroscience, does not erase or overwrite information as was previously thought but merely limits conscious access to it. These findings have a profound impact on consciousness studies and cognitive science in general.
1. Introduction
Consciousness is at the same time what we know best and a complete mystery. Every experience we ever had is the result of our own consciousness. Yet, despite our intimate familiarity with it, consciousness is difficult to define and poorly understood scientifically. We know more about distant galaxies and the deepest regions of the oceans than about the basis for our own experiences. A leading neuroscientist wagered in 1998 that the neural mechanisms of consciousness would be discovered within 25 years. He recently conceded his bet lost. While a complete understanding of consciousness remains elusive, tremendous progress has still been made in this field. As recently as 1996, the International Dictionary of Psychology’s entry on consciousness stated that “nothing worth reading has been written about it”. Now, there are countless books, journals, laboratories, and entire research departments dedicated to this field of enquiry. One fruitful avenue has been to study perception and explore the difference between consciously perceived stimuli and those that remain unconscious. A common way to control the visibility of stimuli is through masking.
Authors:
Mr Damian K F Pang, MSc
The Mutual Benefits of Cohabitation of Solar Panel System and HorticultureThe increasing occurrence of extreme weather events over the past few years has underscored the impact of climate change is having on our planet. As a developed city that has set itself a target of carbon neutrality by the year 2050, Hong Kong must do everything within its power to reduce its carbon emissions in order to contain the global temperature rise to below 1.5°C. Despite Hong Kong’s potential to expand the use of renewable energy, the scarcity of the territory’s land resources means that on top of fierce competition on the usage of every piece of land, owners are already maximising the utility of every square inch on their plot.
In order to improve the visual appeal of urban environments and mitigate urban heat island effects, building owners and property managers are finding ways to carry out greening, such as by transforming conventional roofs into green ones. At the same time, there are also people choosing to install solar photovoltaic systems on their rooftops so as to obtain extra electricity and earn income generated from the Feed-in Tariff (FiT). In addition, some property developers in Hong Kong are considering installing solar panels on unused farmland in a drive to optimise land use. It may seem counterintuitive to combine solar power systems with the cultivation of plants or crops as plants need water, sunlight and soil for growth, and covering them with solar photovoltaic systems goes against the fundamental requirements for their growth. However, with careful planning, these two approaches can be mutually beneficial as well as maximise the utility of our valuable space. This article will explore the advantages, challenges and precautions so required of combining solar photovoltaic systems with greening projects or crop cultivation on rooftops or farmland in Hong Kong.
Solar power in Hong Kong
To truly transition towards a low-carbon economy, it is crucial that Hong Kong increases the proportion of renewable energy in its total energy generation. Hong Kong’s Climate Action Plan 2050 sets out the long-term goal of achieving carbon net zero in its power generation by 2050, with the proportion of its energy coming from renewable sources rising from less than 1% today to 7.5-10% by 2035, and 15% by 2050. As part of this strategy, installing solar power systems on rooftops, hence, is becoming more prevalent. For example, the Action Plan states that new government buildings must dedicate 25% of their available rooftop area to the installation of renewable energy systems, which is significantly higher than the 10% previously stipulated. The Housing Authority similarly must install solar power systems on all new buildings in public housing estates, with a view to using these to generate at least 1.5% of the public electricity supply.
In truth, these targets are relatively low and far less ambitious than those set by other east Asian cities, which has led to criticism from environmental and climate change concerned groups. According to a study by The Hong Kong Polytechnic University, among the 309,000 buildings in Hong Kong, 233,000 are suitable for installing solar photovoltaic systems on their roof or rooftop, which would potentially be able to generate 4,674 GWh of solar energy every year — equivalent to 10.7% of Hong Kong’s energy needs. Hong Kong has had a FiT system in place since 2018, to encourage non-government organisations and private individuals to install renewable energy systems on their property. However, despite the fact that rooftop solar photovoltaic systems can provide an enormous source of renewable energy, the proportion of renewables in Hong Kong’s energy mix has barely risen in the past five years. In fact, the government even reduced the FiT in April 2022, leading to fears that it will discourage others from signing up as they would be unable to recoup the high set-up cost before the scheme’s end in 2033.
Authors:
Mr Kwok Hiu Chung, Senior Programme Officer, CarbonCare InnoLab
Mr Ken Tai, Project Manager, CarbonCare InnoLab
Ringdown: the music by oscillating black holes(1) Introduction
If you pluck a violin string, the string vibrates, driving the air particles around the string to oscillate too, setting up sound waves that propagate in the air. That is why you will hear a note. However, the note will not last long. Through generating sound, the string loses its vibrational energy in the air. The vibrations of the violin string decay. So does the note.Interestingly, a similar phenomenon occurs in perturbed black holes. As two black holes collide, they will merge into one larger and distorted black hole and generate enormous gravitational waves. The distorted black hole is an example of perturbed black hole. These gravitational waves are the oscillations of space-time near the new black hole. Similar to the vibrations of a violin string, the oscillations of black holes do not last long, because black holes are a unique type of celestial object that possesses an event horizon, a single direction highway which once entered, there is no way out. The energy of the gravitational waves propagating around a black hole will likewise dissipate either down to the black-hole horizon by absorption or propagating far away until the waves are far enough for us to detect. Either way, the energy of gravitational waves localised around a black hole is dissipating, and so are the oscillations of the black hole. When the oscillations die down, the distorted black hole becomes a quiet and stationary black hole. The process of a perturbed black hole settling down into a stationary one is called the ringdown phase of a black hole because the process resembles the ringing of musical instruments, such as a bell. Just as a violin string can vibrate in different modes (such as the fundamental mode and overtones), there are also different modes (patterns) of black-hole oscillations. These modes are called the quasinormal modes of black hole, and the oscillation frequencies are called the quasinormal-mode frequencies.
The black-hole ringdown phase is not just of interest to theoretical physics research. It is an actual astrophysical phenomenon which we have detected since the first direct detection of gravitational waves by the Advanced Laser Interferometer Gravitational-Wave Observatory (aLIGO) detectors. The late stage of the first detected gravitational-wave signal, GW150914, clearly shows a ringdown signal emitted by the remnant of a black hole formed by the corresponding black-hole coalescence. Since then, astrophysicists have been studying the ringdown signal contained in the detected gravitational-wave signals extensively.
Author:
Mr Adrian Ka-Wai Chung
Postdoc research associate, Department of Physics, University of Illinois Urbana-Champaign
Member, Illinois Center for Advanced Studies of the Universe
Exploring the potential of long cell-free DNA in cancer liquid biopsyCancer is one of the leading causes of death. One in four people will suffer from cancer in their life time. Many cancers are asymptomatic in early stage. When patients are diagnosed with cancer, they are often in advanced stages, leading to a poorer survival. The key to conquer the disease is to detect cancer at its early stage. Traditionally, cancer diagnosis relies on invasive methods such as tissue biopsy, which can cause complications such as pain, infections and injuries to surrounding organs. As such, there has been an increasing interest in the development of non-invasive methods for cancer testing. This emerging field is called ‘liquid biopsy’.
Recently, cell-free DNA (cfDNA) analysis in bodily fluids has become the focus of liquid biopsy. For instance, in a recent study involving plasma DNA analysis of 20,000 asymptomatic individuals conducted by our team at The Chinese University of Hong Kong, it has been revealed that the circulating Epstein-Barr virus DNA can serve as biomarker for screening nasopharyngeal carcinoma, making a paradigm shift in the proportion of cancer patients identified at early stage when the cancer can be cured. The survival rate was improved 10 times in screened individuals than those in historical cohort, bringing hope to cancer diagnostics using liquid biopsy. Apart from cancer screening, cfDNA analysis can also guide cancer treatment decisions. This is demonstrated by the detection of epidermal growth factor receptor (EGFR) mutations in the plasma of non-small cell lung cancer patients and the subsequent choice of targeted therapy for treatment.
As cfDNA-based liquid biopsy has gradually been gaining popularity in cancer diagnostics, there has been ongoing research efforts in enhancing the understanding of the properties of cfDNA. One key area of research would be epigenetics, which involves chemical modifications without alterations of DNA sequence. Of note, DNA methylation is an important type of epigenetic modification. Recently, based on methylation analysis of plasma DNA, not only could we diagnose cancer, the location of cancer could also be determined. This approach was subsequently applied to screen multiple cancers in a large prospective cohort of 6689 participants and led to the world’s first commercial product of a multi-cancer early detection test called ‘Galleri’ in the market.
Author:
Dr Lois Choy, Department of Chemical Pathology, The Chinese University of Hong Kong
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newsletter (Oct 2023 – Issue 22)
關於香港桂冠論壇歡迎大家來到香港桂冠論壇2023年10月份通訊。
由李兆基基金全額贊助的首屆香港桂冠論壇(下稱「論壇」)即將舉行,並於11月13日在香港科學園開幕,主題為「匯聚頂尖思維.啟發科學成就」。屆時,超過20位邵逸夫獎得獎者、其他世界知名的科學家,及近200名來自30個國家及地區的青年科學家將會出席為期一周的活動。論壇活動的籌備工作現進行得如火如荼,細節安排將近完成,活動內容包括邵逸夫獎得獎者的專題演講、邵逸夫獎得獎者及世界知名科學家們的分科小組討論、青年科學家海報簡報、全球趨勢課題環節等,內容主要圍繞邵逸夫獎涵蓋的三大範疇,分別是天文學、生命科學與醫學、數學科學。當中,邵逸夫獎得獎者及應邀出席論壇的傑出科學家將於演講及小組討論中與青年科學家分享他們對其研究範疇的真知灼見,現在讓大家先睹我們將探討的部份精彩主題:The Tidal Disruption of Stars by Black Holes 、Channelrhodopsins in transgene animals or plants: chances and challenges、Fourier transform as a triangular matrix 等。我們亦會邀請幾位參與論壇的講者分享及討論新科技對科研發展及高等教育這兩個重要方面的影響,講者將通過兩個互相關聯的環節,即:Impact of New Technology on Scientific Development 和 AI and the Teaching of Science,就這個全球趨勢課題進行深入討論。
另一方面,我們將會帶邵逸夫獎得獎者與中學生對談,並參觀本地中學,以提升香港年輕一代對不同科學及科技領域的認識和興趣,這亦是讓邵逸夫獎得獎者親身了解本地中學生活的機會。我們亦與學術伙伴合作,帶青年科學家到本地大學參觀,加深他們對本地大學於科研方面的發展。而論壇參與者更可參觀InnoHK創新研究中心、香港科技園創科體驗館,及香港研發中心,包括港紡織及成衣研發中心有限公司、物流及供應鏈多元技術研發中心、納米及先進材料研發院等,讓他們了解更多香港當前的科研發展項目。此外,我們會與香港數碼科技中心—數碼港合辦「知識轉移 從研發到應用」半天計劃,讓參與者認識香港於數碼科技方面的發展。為讓論壇參與者體驗社區的科學教育,活動還包括參觀香港科學館及太空館,並安排他們參與出席桂冠論壇聯同兩館合作舉行的科學研討會,分別名為「蛋白質摺疊萬花筒」及「銀河系中的星體歷程」,這兩場研討會將會開放給公眾及本地中學生參與。除了學術交流,我們也安排了文化活動,包括參觀西九文化區,並會為論壇參與者預備香港地道美食,讓大家感受香港文化。有關更多論壇的活動、設有網上直播的活動及開放予公眾參與的活動詳情,請密切留意我們的網站及社交媒體!我們期望讓全球更多人認識論壇,因此我們將會邀請本地、駐港及非駐港的媒體機構代表,一同參與此大型學術交流盛會,並向大眾分享一眾頂尖科學家的科研探索之旅。
事實上,作為香港學術界的盛事,論壇已引起了不少媒體的廣泛關注。早前論壇委員會主席唐偉章教授及論壇委員會委員楊綱凱教授接受了不同媒體的訪問,分享他們對論壇的期望和看法。歡迎大家閱讀以下專訪以了解更多:
另外,論壇活動指導委員會顧問及其中一位參與論壇的青年科學家亦會透過不同的媒體,分享他們對論壇的個人見解。大家記得留意!
我們在積極籌備論壇的同時,也繼續以不同形式在社區推動科學發展。我們與Index Game和The Sandbox合辦「Scientists and Their Contributions 立體像素藝術設計比賽」,旨在透過新興的渠道,提升香港年輕一代對不同科學及科技領域的認識和興趣。比賽於7月初接受報名,期間反應熱烈,我們收到超過20隊來自不同中學的學生報名參與,而參賽隊伍已於9月參加了VoxEdit工作坊及諮詢環節,學習使用VoxEdit工具,製作立體像素角色。比賽結果將於本月下旬於我們的網站及社交媒體公佈,獲勝的作品將會以3D打印並於論壇期間展出。
另外,由創新科技署主辦一年一度的創新科技嘉年華快將舉行。創新科技嘉年華2023將於本月28日至11月5日在香港科學園舉行,嘉年華設有超過35個實體展覽和攤位,香港桂冠論壇亦一如以往,參與其中。今年桂冠論壇會再度與法國駐港澳總領事館合作,在展覽中以VR元素展示行星,發掘宇宙中的音樂和聲音,為大家帶來一個獨特且引人入勝的視角和聽覺體驗,讓大家了解宇宙的奧秘。除了VR的體驗,桂冠論壇將會展示其他互動遊戲,歡迎大家親臨我們的攤位,享受在太空漫步的樂趣,探索數學的奧妙,並贏取豐富獎品!更多有關創新科技嘉年華2023的資訊,可瀏覽相關網站。
新記憶種類之證據以及對理解意識和感知之影響摘要
意識是體驗的核心。然而,在科學上,人們對意識的理解仍然十分貧乏。新研究結果揭示,重複展示某物件可讓人有意識地感知微弱、模糊的刺激。這項發現,為一種領先的意識理論所預測的新記憶類型 — 潛意識感官緩衝存儲(SSBS) — 提供了證據。實驗數據也顯示,視覺遮蔽(心理學和神經科學領域廣泛應用的一種技巧)並不如人們先前所認為的那樣,會刪除或覆蓋信息,而只是會限制人們有意識地獲取信息。這些發現對於意識研究和認知科學具有深遠影響。
1. 介紹
意識是我們最清楚知覺,但同時又感到莫明神秘的東西。我們的每一項體驗都是自我意識的結果。可是,雖然意識對我們來說是很貼切熟悉之物,但是卻對之難加定義,而科學上對意識的理解也很貧乏。意識是人類一己體驗的基礎。然而,我們對於遙遠星際及海洋最深處的瞭解,卻遠超於對意識的瞭解。一位著名的神經學科學家曾在 1998 年打賭,說人們將在25年内發現構成意識的神經機制。最近,他承認自己輸了。儘管人們對意識仍然缺乏全面的瞭解,但這個領域的研究還是取得了重大進展。1996 年,《國際心理學詞典》(International Dictionary of Psychology) 在意識這一詞條下寫到:“尚沒有值得一讀的論述”。但是,現在已有多不勝數的書籍、學報、實驗室和研究部門致力推進這方面的研究。其中一項富有成效的方法,便是從感知入手,探索有意識感知的刺激,以及仍然是無意識感知的刺激兩者之間的差異,而遮蔽刺激物是控制刺激物可見度的常見做法。
作者:
Mr Damian K F Pang, MSc
太陽能系統與種植互補優勢隨著近年極端天氣越見頻繁,我們越來越感受到氣候變化所帶來的影響。香港作為已發展城市,訂下2050年達至碳中和的目標後,應該用盡辦法減碳,以控制全球氣溫升幅在攝氏1.5度以下。雖然香港具有發展可再生能源的潛力,但土地資源珍貴,土地使用者盡用每一寸土地作不同用途已經司空見慣,而且不同土地用途亦經常互相競爭。
為了美化環境及減緩熱島效應,很多建築物業主或物業管理人都會選擇進行綠化,把普通的天台改建成綠化天台;同時亦有不少人選擇在屋頂安裝太陽能光伏系統,取得額外電力供應,亦可賺取上網電價收入。此外,香港亦有物業發展商有意在閒置多年的農地上安裝太陽能板,表示希望地盡其用。把太陽能系統與種植植物或農作物結合看似有矛盾的地方,因為植物生長最基本需要水、陽光及土地,而太陽能光伏系統覆蓋在植物上方,正正違反了植物最基本的生長環境要求。但只要細心規劃,兩者其實可以互補優勢,更有效使用珍貴的空間。本文將探討香港在天台或農地將太陽能光伏系統與綠化或耕種農作物結合的好處、挑戰及需要注意的地方。
太陽能在香港的現況
要邁進低碳經濟,香港提升可再生能源在總發電量的比例實在刻不容緩。《香港氣候行動藍圖2050》(《藍圖》)提出2050年前達至淨零碳發電的長遠目標,可再生能源發電比例的目標是由目前的不多於1%,到2035年提升到7.5%至10%,而到2050年提升至15%。其中在建築物天台加建太陽能系統,是越來越普遍的做法。《藍圖》舉例指,新政府建築物須撥出25%的可用天台範圍用作安裝可再生能源系統,比起之前規定的10%提高了不少;房屋委員會亦需要為新落成的公共屋邨大廈安裝太陽能發電系統,以提供至少1.5%的公用電量為目標。
事實上,香港可再生能源發電比例的目標之低,遠遠落後於其他東亞城市,並一直都被關注環境及氣候變化的團體批評。但根據香港理工大學的一項研究顯示,全港30.9萬樓宇中,有23.3萬樓宇適合於頂部或天台安裝太陽能光伏系統,潛在的太陽能發電量可達每年46.74億度電,佔香港能源需求的10.7%。 事實上,香港在2018年起已實施上網電價計劃,吸引非政府機構及個人在其處所安裝可再生能源系統。儘管屋頂太陽能光伏系統提供不少再生能源發電,但從過去五年可再生能源在燃料組合中所佔的比例來看,每年的增幅仍然微乎其微。而政府更於2022年4月調低上網電價,由於安裝太陽能裝置的成本不菲,令有意參與計劃的個人或團體擔心未能在該計劃於2033年年底結束前收回成本。
作者:
郭曉忠(低碳想創坊高級項目主任)
戴宇澄(低碳想創坊項目經理)
鈴盪:黑洞振盪的音樂(1) 引言
如果你撥動一條小提琴的琴弦,琴弦振動的同時,亦驅使它附近的空氣粒子振動,形成聲波在空氣中傳播,這就是為什麼你可以聽到琴音。不過,這樂音不會持久。在發出聲波的同時,琴弦會損失它振動的能量。所以,琴弦的振動會衰減,琴音亦然。有趣的是,受擾動的黑洞都有類似的現象。當兩個黑洞相撞後,它們會合併成一個更大但被扭曲了的黑洞,同時產生重力波。這個被扭曲了的黑洞就是受擾動的黑洞的一個例子。重力波其實就是新形成的黑洞周圍時空的振盪。跟小提琴琴弦相似的是,這些時空的振盪不會持久,因為黑洞是一種具有事件視界的天體。事件視界像是黑洞的一個只可以單向行車的高速公路。任何物件,一旦進入了事件視界,就無法離開。所以在黑洞附近傳播的重力波,要不就是耗散到黑洞的事件視界,要不就是傳播到離黑洞很遠的地方,遠至我們都可以探測到。無論如何,在黑洞附近的重力波總是在散失它的能量,黑洞的振盪亦然。當這些振盪減到很弱時,被扭曲了的黑洞就會變成一個很安靜的靜態黑洞。由於黑洞振盪的衰減過程類似於樂器(例如一個響鈴)發出的樂音的衰減,黑洞振盪的衰減亦都叫做「鈴盪」。就像一條琴弦都有不同的振盪模態(基音和泛音),黑洞振盪都有不同的振盪模態。這些振盪模態命名為黑洞的準簡正模(quasinormal modes),相關的振動頻率則稱為準簡正模頻率(quasinormal-mode frequency)。
黑洞鈴盪不單純是理論物理的一個研究課題,這是一個實在的天文物理現象,打從我們由先進激光干涉儀重力波觀測站(the Advanced Laser Interferometer Gravitational-Wave Observatory, aLIGO)第一次直接量度到重力波時,我們就已經觀察到黑洞鈴盪。首次直接探測到的重力波訊號(GW150914)的末段,就清楚顯出一個由相重力波波源所形成的新黑洞所發出的鈴盪訊號。自此,天體物理學家就廣泛地研究重力波訊號中的鈴盪訊號。
作者︰
鍾嘉唯先生
伊利諾大學厄巴納-香檳分校物理系博士後研究員
伊利諾高等宇宙研究所成員
長片段游離DNA: 癌症檢測新路向癌症在人類眾多殺手中名列前茅,每四個人之中就有一個人會患上癌症。不少早期癌症都沒有任何徵狀。當病人感到不適而求醫時,往往已是癌症晚期,大大降低生存機會。因此,不少科學家都致力研發早期癌症診斷方法,希望能及早診斷出癌症並提供治療,以挽救更多生命。傳統上我們依靠入侵性方法,如活組織檢查作癌症診斷。然而,這些入侵性方法可能導致痛楚、感染或誤傷附近的器官,不少人因而卻步。有見及此,科學界正努力研發各種無創癌症檢測方法,讓癌症檢測變得更安全。這新興領域稱為「液體活檢」。
近年,游離DNA成為了液體活檢領域的中流砥柱。以癌症診斷為例,我們在中文大學的團隊早前進行了涉及二萬人的研究,透過分析血漿內的EB病毒DNA能做到鼻咽癌篩查,接受篩查的人士能在癌症早期就被發現,其存活率亦比沒接受篩查的人士高十倍,為癌症診斷帶來希望。 除了診斷外,游離DNA檢測亦能提供更多關於腫瘤的資訊,幫助醫生為病人制定合適的治療方案。以肺癌為例,現在醫生已能透過檢測血漿中EGFR 基因突變的情況來為病人選擇標靶治療方案。
隨著游離DNA檢測於癌症液體活檢領域逐漸普及,游離DNA特性方面的研究亦取得長足發展。表觀遺傳學涉及不影響DNA序列的化學轉變,是游離DNA特性研究的重要分支。其中,DNA甲基化方面的研究備受關注。血漿游離DNA甲基化分析除了能幫助診斷病人患有癌症外,還能協助確認腫瘤的位置。這種技術已在包括6689名參與者的大型前瞻性研究中證明能應用作多種癌症的篩查,相關的多種癌症早期測試(Galleri)亦已投入市場。
作者:
香港中文大學化學病理學系臨床講師蔡樂怡醫生
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newsletter (Oct 2023 – Issue 22)
關於香港桂冠論壇歡迎大家來到香港桂冠論壇2023年10月份通訊。
由李兆基基金全額贊助的首屆香港桂冠論壇(下稱「論壇」)即將舉行,並於11月13日在香港科學園開幕,主題為「匯聚頂尖思維.啟發科學成就」。屆時,超過20位邵逸夫獎得獎者、其他世界知名的科學家,及近200名來自30個國家及地區的青年科學家將會出席為期一周的活動。論壇活動的籌備工作現進行得如火如荼,細節安排將近完成,活動內容包括邵逸夫獎得獎者的專題演講、邵逸夫獎得獎者及世界知名科學家們的分科小組討論、青年科學家海報簡報、全球趨勢課題環節等,內容主要圍繞邵逸夫獎涵蓋的三大範疇,分別是天文學、生命科學與醫學、數學科學。當中,邵逸夫獎得獎者及應邀出席論壇的傑出科學家將於演講及小組討論中與青年科學家分享他們對其研究範疇的真知灼見,現在讓大家先睹我們將探討的部份精彩主題:The Tidal Disruption of Stars by Black Holes 、Channelrhodopsins in transgene animals or plants: chances and challenges、Fourier transform as a triangular matrix 等。我們亦會邀請幾位參與論壇的講者分享及討論新科技對科研發展及高等教育這兩個重要方面的影響,講者將通過兩個互相關聯的環節,即:Impact of New Technology on Scientific Development 和 AI and the Teaching of Science,就這個全球趨勢課題進行深入討論。
另一方面,我們將會帶邵逸夫獎得獎者與中學生對談,並參觀本地中學,以提升香港年輕一代對不同科學及科技領域的認識和興趣,這亦是讓邵逸夫獎得獎者親身了解本地中學生活的機會。我們亦與學術伙伴合作,帶青年科學家到本地大學參觀,加深他們對本地大學於科研方面的發展。而論壇參與者更可參觀InnoHK創新研究中心、香港科技園創科體驗館,及香港研發中心,包括港紡織及成衣研發中心有限公司、物流及供應鏈多元技術研發中心、納米及先進材料研發院等,讓他們了解更多香港當前的科研發展項目。此外,我們會與香港數碼科技中心—數碼港合辦「知識轉移 從研發到應用」半天計劃,讓參與者認識香港於數碼科技方面的發展。為讓論壇參與者體驗社區的科學教育,活動還包括參觀香港科學館及太空館,並安排他們參與出席桂冠論壇聯同兩館合作舉行的科學研討會,分別名為「蛋白質摺疊萬花筒」及「銀河系中的星體歷程」,這兩場研討會將會開放給公眾及本地中學生參與。除了學術交流,我們也安排了文化活動,包括參觀西九文化區,並會為論壇參與者預備香港地道美食,讓大家感受香港文化。有關更多論壇的活動、設有網上直播的活動及開放予公眾參與的活動詳情,請密切留意我們的網站及社交媒體!我們期望讓全球更多人認識論壇,因此我們將會邀請本地、駐港及非駐港的媒體機構代表,一同參與此大型學術交流盛會,並向大眾分享一眾頂尖科學家的科研探索之旅。
事實上,作為香港學術界的盛事,論壇已引起了不少媒體的廣泛關注。早前論壇委員會主席唐偉章教授及論壇委員會委員楊綱凱教授接受了不同媒體的訪問,分享他們對論壇的期望和看法。歡迎大家閱讀以下專訪以了解更多:
另外,論壇活動指導委員會顧問及其中一位參與論壇的青年科學家亦會透過不同的媒體,分享他們對論壇的個人見解。大家記得留意!
我們在積極籌備論壇的同時,也繼續以不同形式在社區推動科學發展。我們與Index Game和The Sandbox合辦「Scientists and Their Contributions 立體像素藝術設計比賽」,旨在透過新興的渠道,提升香港年輕一代對不同科學及科技領域的認識和興趣。比賽於7月初接受報名,期間反應熱烈,我們收到超過20隊來自不同中學的學生報名參與,而參賽隊伍已於9月參加了VoxEdit工作坊及諮詢環節,學習使用VoxEdit工具,製作立體像素角色。比賽結果將於本月下旬於我們的網站及社交媒體公佈,獲勝的作品將會以3D打印並於論壇期間展出。
另外,由創新科技署主辦一年一度的創新科技嘉年華快將舉行。創新科技嘉年華2023將於本月28日至11月5日在香港科學園舉行,嘉年華設有超過35個實體展覽和攤位,香港桂冠論壇亦一如以往,參與其中。今年桂冠論壇會再度與法國駐港澳總領事館合作,在展覽中以VR元素展示行星,發掘宇宙中的音樂和聲音,為大家帶來一個獨特且引人入勝的視角和聽覺體驗,讓大家了解宇宙的奧秘。除了VR的體驗,桂冠論壇將會展示其他互動遊戲,歡迎大家親臨我們的攤位,享受在太空漫步的樂趣,探索數學的奧妙,並贏取豐富獎品!更多有關創新科技嘉年華2023的資訊,可瀏覽相關網站。
新記憶種類之證據以及對理解意識和感知之影響摘要
意識是體驗的核心。然而,在科學上,人們對意識的理解仍然十分貧乏。新研究結果揭示,重複展示某物件可讓人有意識地感知微弱、模糊的刺激。這項發現,為一種領先的意識理論所預測的新記憶類型 — 潛意識感官緩衝存儲(SSBS) — 提供了證據。實驗數據也顯示,視覺遮蔽(心理學和神經科學領域廣泛應用的一種技巧)並不如人們先前所認為的那樣,會刪除或覆蓋信息,而只是會限制人們有意識地獲取信息。這些發現對於意識研究和認知科學具有深遠影響。
1. 介紹
意識是我們最清楚知覺,但同時又感到莫明神秘的東西。我們的每一項體驗都是自我意識的結果。可是,雖然意識對我們來說是很貼切熟悉之物,但是卻對之難加定義,而科學上對意識的理解也很貧乏。意識是人類一己體驗的基礎。然而,我們對於遙遠星際及海洋最深處的瞭解,卻遠超於對意識的瞭解。一位著名的神經學科學家曾在 1998 年打賭,說人們將在25年内發現構成意識的神經機制。最近,他承認自己輸了。儘管人們對意識仍然缺乏全面的瞭解,但這個領域的研究還是取得了重大進展。1996 年,《國際心理學詞典》(International Dictionary of Psychology) 在意識這一詞條下寫到:“尚沒有值得一讀的論述”。但是,現在已有多不勝數的書籍、學報、實驗室和研究部門致力推進這方面的研究。其中一項富有成效的方法,便是從感知入手,探索有意識感知的刺激,以及仍然是無意識感知的刺激兩者之間的差異,而遮蔽刺激物是控制刺激物可見度的常見做法。
作者:
Mr Damian K F Pang, MSc
太陽能系統與種植互補優勢隨著近年極端天氣越見頻繁,我們越來越感受到氣候變化所帶來的影響。香港作為已發展城市,訂下2050年達至碳中和的目標後,應該用盡辦法減碳,以控制全球氣溫升幅在攝氏1.5度以下。雖然香港具有發展可再生能源的潛力,但土地資源珍貴,土地使用者盡用每一寸土地作不同用途已經司空見慣,而且不同土地用途亦經常互相競爭。
為了美化環境及減緩熱島效應,很多建築物業主或物業管理人都會選擇進行綠化,把普通的天台改建成綠化天台;同時亦有不少人選擇在屋頂安裝太陽能光伏系統,取得額外電力供應,亦可賺取上網電價收入。此外,香港亦有物業發展商有意在閒置多年的農地上安裝太陽能板,表示希望地盡其用。把太陽能系統與種植植物或農作物結合看似有矛盾的地方,因為植物生長最基本需要水、陽光及土地,而太陽能光伏系統覆蓋在植物上方,正正違反了植物最基本的生長環境要求。但只要細心規劃,兩者其實可以互補優勢,更有效使用珍貴的空間。本文將探討香港在天台或農地將太陽能光伏系統與綠化或耕種農作物結合的好處、挑戰及需要注意的地方。
太陽能在香港的現況
要邁進低碳經濟,香港提升可再生能源在總發電量的比例實在刻不容緩。《香港氣候行動藍圖2050》(《藍圖》)提出2050年前達至淨零碳發電的長遠目標,可再生能源發電比例的目標是由目前的不多於1%,到2035年提升到7.5%至10%,而到2050年提升至15%。其中在建築物天台加建太陽能系統,是越來越普遍的做法。《藍圖》舉例指,新政府建築物須撥出25%的可用天台範圍用作安裝可再生能源系統,比起之前規定的10%提高了不少;房屋委員會亦需要為新落成的公共屋邨大廈安裝太陽能發電系統,以提供至少1.5%的公用電量為目標。
事實上,香港可再生能源發電比例的目標之低,遠遠落後於其他東亞城市,並一直都被關注環境及氣候變化的團體批評。但根據香港理工大學的一項研究顯示,全港30.9萬樓宇中,有23.3萬樓宇適合於頂部或天台安裝太陽能光伏系統,潛在的太陽能發電量可達每年46.74億度電,佔香港能源需求的10.7%。 事實上,香港在2018年起已實施上網電價計劃,吸引非政府機構及個人在其處所安裝可再生能源系統。儘管屋頂太陽能光伏系統提供不少再生能源發電,但從過去五年可再生能源在燃料組合中所佔的比例來看,每年的增幅仍然微乎其微。而政府更於2022年4月調低上網電價,由於安裝太陽能裝置的成本不菲,令有意參與計劃的個人或團體擔心未能在該計劃於2033年年底結束前收回成本。
作者:
郭曉忠(低碳想創坊高級項目主任)
戴宇澄(低碳想創坊項目經理)
鈴盪:黑洞振盪的音樂(1) 引言
如果你撥動一條小提琴的琴弦,琴弦振動的同時,亦驅使它附近的空氣粒子振動,形成聲波在空氣中傳播,這就是為什麼你可以聽到琴音。不過,這樂音不會持久。在發出聲波的同時,琴弦會損失它振動的能量。所以,琴弦的振動會衰減,琴音亦然。有趣的是,受擾動的黑洞都有類似的現象。當兩個黑洞相撞後,它們會合併成一個更大但被扭曲了的黑洞,同時產生重力波。這個被扭曲了的黑洞就是受擾動的黑洞的一個例子。重力波其實就是新形成的黑洞周圍時空的振盪。跟小提琴琴弦相似的是,這些時空的振盪不會持久,因為黑洞是一種具有事件視界的天體。事件視界像是黑洞的一個只可以單向行車的高速公路。任何物件,一旦進入了事件視界,就無法離開。所以在黑洞附近傳播的重力波,要不就是耗散到黑洞的事件視界,要不就是傳播到離黑洞很遠的地方,遠至我們都可以探測到。無論如何,在黑洞附近的重力波總是在散失它的能量,黑洞的振盪亦然。當這些振盪減到很弱時,被扭曲了的黑洞就會變成一個很安靜的靜態黑洞。由於黑洞振盪的衰減過程類似於樂器(例如一個響鈴)發出的樂音的衰減,黑洞振盪的衰減亦都叫做「鈴盪」。就像一條琴弦都有不同的振盪模態(基音和泛音),黑洞振盪都有不同的振盪模態。這些振盪模態命名為黑洞的準簡正模(quasinormal modes),相關的振動頻率則稱為準簡正模頻率(quasinormal-mode frequency)。
黑洞鈴盪不單純是理論物理的一個研究課題,這是一個實在的天文物理現象,打從我們由先進激光干涉儀重力波觀測站(the Advanced Laser Interferometer Gravitational-Wave Observatory, aLIGO)第一次直接量度到重力波時,我們就已經觀察到黑洞鈴盪。首次直接探測到的重力波訊號(GW150914)的末段,就清楚顯出一個由相重力波波源所形成的新黑洞所發出的鈴盪訊號。自此,天體物理學家就廣泛地研究重力波訊號中的鈴盪訊號。
作者︰
鍾嘉唯先生
伊利諾大學厄巴納-香檳分校物理系博士後研究員
伊利諾高等宇宙研究所成員
長片段游離DNA: 癌症檢測新路向癌症在人類眾多殺手中名列前茅,每四個人之中就有一個人會患上癌症。不少早期癌症都沒有任何徵狀。當病人感到不適而求醫時,往往已是癌症晚期,大大降低生存機會。因此,不少科學家都致力研發早期癌症診斷方法,希望能及早診斷出癌症並提供治療,以挽救更多生命。傳統上我們依靠入侵性方法,如活組織檢查作癌症診斷。然而,這些入侵性方法可能導致痛楚、感染或誤傷附近的器官,不少人因而卻步。有見及此,科學界正努力研發各種無創癌症檢測方法,讓癌症檢測變得更安全。這新興領域稱為「液體活檢」。
近年,游離DNA成為了液體活檢領域的中流砥柱。以癌症診斷為例,我們在中文大學的團隊早前進行了涉及二萬人的研究,透過分析血漿內的EB病毒DNA能做到鼻咽癌篩查,接受篩查的人士能在癌症早期就被發現,其存活率亦比沒接受篩查的人士高十倍,為癌症診斷帶來希望。 除了診斷外,游離DNA檢測亦能提供更多關於腫瘤的資訊,幫助醫生為病人制定合適的治療方案。以肺癌為例,現在醫生已能透過檢測血漿中EGFR 基因突變的情況來為病人選擇標靶治療方案。
隨著游離DNA檢測於癌症液體活檢領域逐漸普及,游離DNA特性方面的研究亦取得長足發展。表觀遺傳學涉及不影響DNA序列的化學轉變,是游離DNA特性研究的重要分支。其中,DNA甲基化方面的研究備受關注。血漿游離DNA甲基化分析除了能幫助診斷病人患有癌症外,還能協助確認腫瘤的位置。這種技術已在包括6689名參與者的大型前瞻性研究中證明能應用作多種癌症的篩查,相關的多種癌症早期測試(Galleri)亦已投入市場。
作者:
香港中文大學化學病理學系臨床講師蔡樂怡醫生
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newsletter (Oct 2023 – Issue 22)
关于香港桂冠论坛欢迎大家来到香港桂冠论坛2023年10月份通讯。
由李兆基基金全额赞助的首届香港桂冠论坛(下称「论坛」)即将举行,并于11月13日在香港科学园开幕,主题为「汇聚顶尖思维.启发科学成就」。届时,超过20位邵逸夫奖得奖者、其他世界知名的科学家,及近200名来自30个国家及地区的青年科学家将会出席为期一周的活动。论坛活动的筹备工作现进行得如火如荼,细节安排将近完成,活动内容包括邵逸夫奖得奖者的专题演讲、邵逸夫奖得奖者及世界知名科学家们的分科小组讨论、青年科学家海报简报、全球趋势课题环节等,内容主要围绕邵逸夫奖涵盖的三大范畴,分别是天文学、生命科学与医学、数学科学。当中,邵逸夫奖得奖者及应邀出席论坛的杰出科学家将于演讲及小组讨论中与青年科学家分享他们对其研究范畴的真知灼见,现在让大家先睹我们将探讨的部份精彩主题:The Tidal Disruption of Stars by Black Holes 、Channelrhodopsins in transgene animals or plants: chances and challenges、Fourier transform as a triangular matrix 等。我们亦会邀请几位参与论坛的讲者分享及讨论新科技对科研发展及高等教育这两个重要方面的影响,讲者将通过两个互相关联的环节,即:Impact of New Technology on Scientific Development 和 AI and the Teaching of Science,就这个全球趋势课题进行深入讨论。
另一方面,我们将会带邵逸夫奖得奖者与中学生对谈,并参观本地中学,以提升香港年轻一代对不同科学及科技领域的认识和兴趣,这亦是让邵逸夫奖得奖者亲身了解本地中学生活的机会。我们亦与学术伙伴合作,带青年科学家到本地大学参观,加深他们对本地大学于科研方面的发展。而论坛参与者更可参观InnoHK创新研究中心、香港科技园创科体验馆,及香港研发中心,包括港纺织及成衣研发中心有限公司、物流及供应链多元技术研发中心、纳米及先进材料研发院等,让他们了解更多香港当前的科研发展项目。此外,我们会与香港数码科技中心—数码港合办「知识转移 从研发到应用」半天计划,让参与者认识香港于数码科技方面的发展。为让论坛参与者体验社区的科学教育,活动还包括参观香港科学馆及太空馆,并安排他们参与出席桂冠论坛联同两馆合作举行的科学研讨会,分别名为「蛋白质折叠万花筒」及「银河系中的星体历程」,这两场研讨会将会开放给公众及本地中学生参与。除了学术交流,我们也安排了文化活动,包括参观西九文化区,并会为论坛参与者预备香港地道美食,让大家感受香港文化。有关更多论坛的活动、设有网上直播的活动及开放予公众参与的活动详情,请密切留意我们的网站及社交媒体!我们期望让全球更多人认识论坛,因此我们将会邀请本地、驻港及非驻港的媒体机构代表,一同参与此大型学术交流盛会,并向大众分享一众顶尖科学家的科研探索之旅。
事实上,作为香港学术界的盛事,论坛已引起了不少媒体的广泛关注。早前论坛委员会主席唐伟章教授及论坛委员会委员杨纲凯教授接受了不同媒体的访问,分享他们对论坛的期望和看法。欢迎大家阅读以下专访以了解更多:
另外,论坛活动指导委员会顾问及其中一位参与论坛的青年科学家亦会透过不同的媒体,分享他们对论坛的个人见解。大家记得留意!
我们在积极筹备论坛的同时,也继续以不同形式在社区推动科学发展。我们与Index Game和The Sandbox合办「Scientists and Their Contributions 立体像素艺术设计比赛」,旨在透过新兴的渠道,提升香港年轻一代对不同科学及科技领域的认识和兴趣。比赛于7月初接受报名,期间反应热烈,我们收到超过20队来自不同中学的学生报名参与,而参赛队伍已于9月参加了VoxEdit工作坊及咨询环节,学习使用VoxEdit工具,制作立体像素角色。比赛结果将于本月下旬于我们的网站及社交媒体公布,获胜的作品将会以3D打印并于论坛期间展出。
另外,由创新科技署主办一年一度的创新科技嘉年华快将举行。创新科技嘉年华2023将于本月28日至11月5日在香港科学园举行,嘉年华设有超过35个实体展览和摊位,香港桂冠论坛亦一如以往,参与其中。今年桂冠论坛会再度与法国驻港澳总领事馆合作,在展览中以VR元素展示行星,发掘宇宙中的音乐和声音,为大家带来一个独特且引人入胜的视角和听觉体验,让大家了解宇宙的奥秘。除了VR的体验,桂冠论坛将会展示其他互动游戏,欢迎大家亲临我们的摊位,享受在太空漫步的乐趣,探索数学的奥妙,并赢取丰富奖品!更多有关创新科技嘉年华2023的资讯,可浏览相关网站。
新记忆种类之证据以及对理解意识和感知之影响摘要
意识是体验的核心。然而,在科学上,人们对意识的理解仍然十分贫乏。新研究结果揭示,重复展示某物件可让人有意识地感知微弱、模糊的刺激。这项发现,为一种领先的意识理论所预测的新记忆类型 — 潜意识感官缓冲存储(SSBS) — 提供了证据。实验数据也显示,视觉遮蔽(心理学和神经科学领域广泛应用的一种技巧)并不如人们先前所认为的那样,会删除或覆盖信息,而只是会限制人们有意识地获取信息。这些发现对于意识研究和认知科学具有深远影响。
1. 介绍
意识是我们最清楚知觉,但同时又感到莫明神秘的东西。我们的每一项体验都是自我意识的结果。可是,虽然意识对我们来说是很贴切熟悉之物,但是却对之难加定义,而科学上对意识的理解也很贫乏。意识是人类一己体验的基础。然而,我们对于遥远星际及海洋最深处的了解,却远超于对意识的了解。一位著名的神经学科学家曾在 1998 年打赌,说人们将在25年内发现构成意识的神经机制。最近,他承认自己输了。尽管人们对意识仍然缺乏全面的了解,但这个领域的研究还是取得了重大进展。1996 年,《国际心理学词典》(International Dictionary of Psychology) 在意识这一词条下写到:“尚没有值得一读的论述”。但是,现在已有多不胜数的书籍、学报、实验室和研究部门致力推进这方面的研究。其中一项富有成效的方法,便是从感知入手,探索有意识感知的刺激,以及仍然是无意识感知的刺激两者之间的差异,而遮蔽刺激物是控制刺激物可见度的常见做法。
作者:
Mr Damian K F Pang, MSc
太阳能系统与种植互补优势随著近年极端天气越见频繁,我们越来越感受到气候变化所带来的影响。香港作为已发展城市,订下2050年达至碳中和的目标后,应该用尽办法减碳,以控制全球气温升幅在摄氏1.5度以下。虽然香港具有发展可再生能源的潜力,但土地资源珍贵,土地使用者尽用每一寸土地作不同用途已经司空见惯,而且不同土地用途亦经常互相竞争。
为了美化环境及减缓热岛效应,很多建筑物业主或物业管理人都会选择进行绿化,把普通的天台改建成绿化天台;同时亦有不少人选择在屋顶安装太阳能光伏系统,取得额外电力供应,亦可赚取上网电价收入。此外,香港亦有物业发展商有意在闲置多年的农地上安装太阳能板,表示希望地尽其用。把太阳能系统与种植植物或农作物结合看似有矛盾的地方,因为植物生长最基本需要水、阳光及土地,而太阳能光伏系统覆盖在植物上方,正正违反了植物最基本的生长环境要求。但只要细心规划,两者其实可以互补优势,更有效使用珍贵的空间。本文将探讨香港在天台或农地将太阳能光伏系统与绿化或耕种农作物结合的好处、挑战及需要注意的地方。
太阳能在香港的现况
要迈进低碳经济,香港提升可再生能源在总发电量的比例实在刻不容缓。《香港气候行动蓝图2050》(《蓝图》)提出2050年前达至净零碳发电的长远目标,可再生能源发电比例的目标是由目前的不多于1%,到2035年提升到7.5%至10%,而到2050年提升至15%。其中在建筑物天台加建太阳能系统,是越来越普遍的做法。《蓝图》举例指,新政府建筑物须拨出25%的可用天台范围用作安装可再生能源系统,比起之前规定的10%提高了不少;房屋委员会亦需要为新落成的公共屋邨大厦安装太阳能发电系统,以提供至少1.5%的公用电量为目标。
事实上,香港可再生能源发电比例的目标之低,远远落后于其他东亚城市,并一直都被关注环境及气候变化的团体批评。但根据香港理工大学的一项研究显示,全港30.9万楼宇中,有23.3万楼宇适合于顶部或天台安装太阳能光伏系统,潜在的太阳能发电量可达每年46.74亿度电,占香港能源需求的10.7%。 事实上,香港在2018年起已实施上网电价计划,吸引非政府机构及个人在其处所安装可再生能源系统。尽管屋顶太阳能光伏系统提供不少再生能源发电,但从过去五年可再生能源在燃料组合中所占的比例来看,每年的增幅仍然微乎其微。而政府更于2022年4月调低上网电价,由于安装太阳能装置的成本不菲,令有意参与计划的个人或团体担心未能在该计划于2033年年底结束前收回成本。
作者:
郭晓忠(低碳想创坊高级项目主任)
戴宇澄(低碳想创坊项目经理)
铃荡:黑洞振荡的音乐(1) 引言
如果你拨动一条小提琴的琴弦,琴弦振动的同时,亦驱使它附近的空气粒子振动,形成声波在空气中传播,这就是为什么你可以听到琴音。不过,这乐音不会持久。在发出声波的同时,琴弦会损失它振动的能量。所以,琴弦的振动会衰减,琴音亦然。有趣的是,受扰动的黑洞都有类似的现象。当两个黑洞相撞后,它们会合并成一个更大但被扭曲了的黑洞,同时产生重力波。这个被扭曲了的黑洞就是受扰动的黑洞的一个例子。重力波其实就是新形成的黑洞周围时空的振荡。跟小提琴琴弦相似的是,这些时空的振荡不会持久,因为黑洞是一种具有事件视界的天体。事件视界像是黑洞的一个只可以单向行车的高速公路。任何物件,一旦进入了事件视界,就无法离开。所以在黑洞附近传播的重力波,要不就是耗散到黑洞的事件视界,要不就是传播到离黑洞很远的地方,远至我们都可以探测到。无论如何,在黑洞附近的重力波总是在散失它的能量,黑洞的振荡亦然。当这些振荡减到很弱时,被扭曲了的黑洞就会变成一个很安静的静态黑洞。由于黑洞振荡的衰减过程类似于乐器(例如一个响铃)发出的乐音的衰减,黑洞振荡的衰减亦都叫做「铃荡」。就像一条琴弦都有不同的振荡模态(基音和泛音),黑洞振荡都有不同的振荡模态。这些振荡模态命名为黑洞的准简正模(quasinormal modes),相关的振动频率则称为准简正模频率(quasinormal-mode frequency)。
黑洞铃荡不单纯是理论物理的一个研究课题,这是一个实在的天文物理现象,打从我们由先进激光干涉仪重力波观测站(the Advanced Laser Interferometer Gravitational-Wave Observatory, aLIGO)第一次直接量度到重力波时,我们就已经观察到黑洞铃荡。首次直接探测到的重力波讯号(GW150914)的末段,就清楚显出一个由相重力波波源所形成的新黑洞所发出的铃荡讯号。自此,天体物理学家就广泛地研究重力波讯号中的铃荡讯号。
作者︰
钟嘉唯先生
伊利诺大学厄巴纳-香槟分校物理系博士后研究员
伊利诺高等宇宙研究所成员
长片段游离DNA: 癌症检测新路向癌症在人类众多杀手中名列前茅,每四个人之中就有一个人会患上癌症。不少早期癌症都没有任何征状。当病人感到不适而求医时,往往已是癌症晚期,大大降低生存机会。因此,不少科学家都致力研发早期癌症诊断方法,希望能及早诊断出癌症并提供治疗,以挽救更多生命。传统上我们依靠入侵性方法,如活组织检查作癌症诊断。然而,这些入侵性方法可能导致痛楚、感染或误伤附近的器官,不少人因而却步。有见及此,科学界正努力研发各种无创癌症检测方法,让癌症检测变得更安全。这新兴领域称为「液体活检」。
近年,游离DNA成为了液体活检领域的中流砥柱。以癌症诊断为例,我们在中文大学的团队早前进行了涉及二万人的研究,透过分析血浆内的EB病毒DNA能做到鼻咽癌筛查,接受筛查的人士能在癌症早期就被发现,其存活率亦比没接受筛查的人士高十倍,为癌症诊断带来希望。 除了诊断外,游离DNA检测亦能提供更多关于肿瘤的资讯,帮助医生为病人制定合适的治疗方案。以肺癌为例,现在医生已能透过检测血浆中EGFR 基因突变的情况来为病人选择标靶治疗方案。
随著游离DNA检测于癌症液体活检领域逐渐普及,游离DNA特性方面的研究亦取得长足发展。表观遗传学涉及不影响DNA序列的化学转变,是游离DNA特性研究的重要分支。其中,DNA甲基化方面的研究备受关注。血浆游离DNA甲基化分析除了能帮助诊断病人患有癌症外,还能协助确认肿瘤的位置。这种技术已在包括6689名参与者的大型前瞻性研究中证明能应用作多种癌症的筛查,相关的多种癌症早期测试(Galleri)亦已投入市场。
作者:
香港中文大学化学病理学系临床讲师蔡乐怡医生






























